9-cyclopropyl-6-fluoro-7-(octahydropyrrolo[3,4-b]pyridin-6-yl)isothiazolo[5,4-b][1,8]naphthyridine-3,4(2H,9H)-dione hydrochloride | 922491-17-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 9-cyclopropyl-6-fluoro-7-(octahydropyrrolo[3,4-b]pyridin-6-yl)isothiazolo[5,4-b][1,8]naphthyridine-3,4(2H,9H)-dione hydrochloride
• 英文别名: 7-(1,2,3,4,4a,5,7,7a-Octahydropyrrolo[3,4-b]pyridin-6-yl)-9-cyclopropyl-6-fluoro-[1,2]thiazolo[5,4-b][1,8]naphthyridine-3,4-dione;hydrochloride
• CAS: 922491-17-6
• 化学式: C₁₉H₂₀FN₅O₂S*ClH
• 分子量: 437.925
• InChiKey: BVMLVQJYWUSBMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.38
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  103
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• 8-methoxy-9H-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents
  申请人：Bradbury James Barton

  公开号：US20070049586A1

  公开（公告）日：2007-03-01

  The invention provides compound and salts of Formula I and II, disclosed herein, which includes compounds of Formula A and Formula B: Such compounds possess useful antimicrobial activity. The variables R 2 , R 3 , R 5 , R 6 , R 7 , and R 9 shown in Formula A and B are defined herein. Certain compounds of Formula I and Formula II disclosed herein are potent and/or selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of a compound of Formula I or Formula II and one or more other active agents. The invention also provides methods for treating microbial infections in animals.

  本发明提供了公式I和II的化合物和盐，其中包括公式A和公式B的化合物：这些化合物具有有用的抗微生物活性。公式A和B中显示的变量R2、R3、R5、R6、R7和R9在此定义。本文所披露的公式I和公式II的某些化合物是强效和/或选择性的细菌DNA合成和细菌复制抑制剂。本发明还提供了抗微生物组合物，包括含有公式I或公式II中一个或多个化合物和一个或多个载体、赋形剂或稀释剂的制药组合物。这些组合物可以仅包含公式I或公式II中的一个化合物作为唯一活性剂，也可以包含公式I或公式II中的一个化合物和一个或多个其他活性剂的组合物。本发明还提供了治疗动物微生物感染的方法。
• 8-METHOXY-9H-ISOTHIAZOLO[5,4-B]QUINOLINE-3,4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS
  申请人：Bradbury Barton James

  公开号：US20120040959A1

  公开（公告）日：2012-02-16

  The invention provides compound and salts of Formula I and II, disclosed herein, which includes compounds of Formula A and Formula B: Such compounds possess useful antimicrobial activity. The variables R 2 , R 3 , R 5 , R 6 , R 7 , and R 9 shown in Formula A and B are defined herein. Certain compounds of Formula I and Formula II disclosed herein are potent and/or selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of a compound of Formula I or Formula II and one or more other active agents. The invention also provides methods for treating microbial infections in animals.

  本发明提供了公式I和II的化合物和盐，其中包括公式A和公式B的化合物：这些化合物具有有用的抗微生物活性。 公式A和B中显示的变量R2、R3、R5、R6、R7和R9在此定义。 本文所披露的某些公式I和公式II的化合物是细菌DNA合成和细菌复制的有效和/或选择性抑制剂。 本发明还提供了抗微生物组合物，包括含有一个或多个公式I或公式II化合物的制药组合物和一个或多个载体、赋形剂或稀释剂。 这样的组合物可以仅包含公式I或公式II的化合物作为唯一活性剂，也可以包含公式I或公式II的化合物和一个或多个其他活性剂的组合物。 本发明还提供了治疗动物微生物感染的方法。
• US8044204B2
  申请人：——

  公开号：US8044204B2

  公开（公告）日：2011-10-25
• US8946422B2
  申请人：——

  公开号：US8946422B2

  公开（公告）日：2015-02-03
• [EN] 8-METHOXY-9H-ISOTHIAZOLO[5,4-B]QUINOLINE-3,4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS<br/>[FR] 8-METHOXY-9H-ISOTHIAZOLO[5,4-B]QUINOLINE-3,4-DIONES ET COMPOSÉS AFFÉRENTS COMME AGENTS ANTI-INFECTIEUX
  申请人：ACHILLION PHARMACEUTICALS INC

  公开号：WO2007014308A1

  公开（公告）日：2007-02-01

  [EN] The invention provides compound and salts of Formula (I) and (II), disclosed herein, which includes compounds of Formula (A) and Formula (B) such compounds possess useful antimicrobial activity. The variables R₂, R₃, R₅, R₆, R₇, and R₉ shown in Formula A and B are defined herein. Certain compounds of Formula (I) and Formula (II) disclosed herein are potent and/ or selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula (I) or Formula (II) and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula (I) or Formula (II) as the only active agent or may contain a combination of a compound of Formula I or Formula II and one or more other active agents. The invention also provides methods for treating microbial infections in animals.
  [FR] L'invention concerne un composé et des sels représentés par les formules (I) et (II) décrites ici, qui incluent des composés de formule (A) et de formule (B) , lesdits composés possédant une activité antimicrobienne utile. Les variables R₂, R₃, R₅, R₆, R₇, et R₉ qui apparaissent dans les formules A et B sont définies ici. Certains composés de la formule (I) et de la formule (II) décrits ici sont des inhibiteurs puissants et/ou sélectifs de la synthèse de l'ADN bactérien et de la réplication bactérienne. L'invention concerne également des compositions antimicrobiennes, y compris des compositions pharmaceutiques contenant un ou plusieurs composés de formule (I) ou de formule (II) et un ou plusieurs vecteurs, excipients ou diluants. De telles compositions peuvent contenir un composé de formule (I) ou de formule (II) comme seul principe actif, ou peuvent contenir une combinaison de composés de formule (I) ou de formule (II) et un ou plusieurs autres principes actifs. De plus, l'invention concerne des procédés de traitement des infections microbiennes chez l'animal.