9-tert.Butyl-3-oxa-spiro<5.5>undecan | 3187-25-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 9-tert.Butyl-3-oxa-spiro<5.5>undecan
• 英文别名: 9-Tert-butyl-3-oxaspiro[5.5]undecane
• CAS: 3187-25-5
• 化学式: C₁₄H₂₆O
• 分子量: 210.36
• InChiKey: KCRUKCAIWWWASP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Tricyclic degraders of Ikaros and Aiolos
  申请人：C4 Therapeutics, Inc.

  公开号：US11407732B1

  公开（公告）日：2022-08-09

  Tricyclic cereblon binders for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway for therapeutic applications are described.

  介绍了用于治疗的三环脑龙结合剂，可通过泛素蛋白酶体途径降解 Ikaros 或 Aiolos。
• CEREBLON BINDERS FOR THE DEGRADATION OF IKAROS
  申请人：C4 Therapeutics, Inc.

  公开号：US20210009559A1

  公开（公告）日：2021-01-14

  The present invention provides cereblon binders for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway along with their use in therapeutic applications as described herein.
• COMPOUNDS FOR THE DEGRADATION OF BRD9 OR MTH1
  申请人：C4 Therapeutics, Inc.

  公开号：US20210198256A1

  公开（公告）日：2021-07-01

  Compounds that degrade BRD9 or MTH1 via the ubiquitin proteasome pathway in a subject in need thereof for therapeutic applications are provided. The compounds provided have an E3 Ubiquitin Ligase targeting moiety (Degron) that is linked to a Targeting Ligand for BRD9 or MTH1.