Poly(oxy-1,2-ethanediyl), I+/--hydro-I-(3-aminopropoxy)-, ether with 2,2-bis(hydroxymethyl)-1,3-propanediol (4:1) | 804514-67-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Poly(oxy-1,2-ethanediyl), I+/--hydro-I-(3-aminopropoxy)-, ether with 2,2-bis(hydroxymethyl)-1,3-propanediol (4:1)
• 英文别名: 3-[2-[3-[2-(3-aminopropoxy)ethoxy]-2,2-bis[2-(3-aminopropoxy)ethoxymethyl]propoxy]ethoxy]propan-1-amine
• CAS: 804514-67-8
• 化学式: C₂₅H₅₆N₄O₈
• 分子量: 540.7
• InChiKey: DOUUDSLNKUPHCX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.2
• 重原子数：
  37
• 可旋转键数：
  32
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  178
• 氢给体数：
  4
• 氢受体数：
  12

文献信息

• HYDROGELS WITH BIODEGRADABLE CROSSLINKING
  申请人：ProLynx LLC

  公开号：US20170312368A1

  公开（公告）日：2017-11-02

  Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals.

  描述了在适当的pH和温度条件下，由于交联化合物通过消除反应而降解的水凝胶。这些水凝胶可以用于输送各种药剂，如药物。
• Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
  申请人：Konradi W. Andrei

  公开号：US20070021555A1

  公开（公告）日：2007-01-25

  Disclosed is a process for preparing polymer conjugates of agricultural, therapeutic, and food additive compounds using Mitsunobu conditions.

  揭示了一种使用Mitsunobu条件制备农业、治疗和食品添加剂化合物的聚合物共轭物的过程。
• Methods and compositions for treating liquid tumors
  申请人：Messersmith Elizabeth

  公开号：US20090312353A1

  公开（公告）日：2009-12-17

  The application relates to a method of using compositions having anti-alpha-4 integrin and/or anti-alpha-9 integrin activity to inhibit liquid tumor growth, malignancies thereof and/or development of metastases thereof that involve expression of an alpha-4 integrin and/or alpha-9 integrin. Pharmaceutical compositions and combination therapies (for example, with chemotherapies) for the inhibition of liquid tumor growth, malignancies thereof and/or development of metastases thereof are also provided.

  本申请涉及使用具有抗α-4整合素和/或抗α-9整合素活性的组合物的方法，以抑制液体肿瘤的生长、其恶性肿瘤以及涉及表达α-4整合素和/或α-9整合素的转移的发展。还提供了用于抑制液体肿瘤的生长、其恶性肿瘤以及涉及表达α-4整合素和/或α-9整合素的转移的发展的药物组合物和联合治疗（例如，与化疗联合治疗）。
• Preparation of Polymer Conjugates of Therapeutic, Agricultural, and Food Additive Compounds
  申请人：Konradi Andrei W.

  公开号：US20130018187A1

  公开（公告）日：2013-01-17

  Disclosed is a process for preparing polymer conjugates of agricultural, therapeutic, and food additive compounds using Mitsunobu conditions.

  揭示了一种使用Mitsunobu条件制备农业、治疗和食品添加剂化合物的高分子共轭物的过程。
• Multimeric VLA-4 Antagonists Comprising Polymers Moieties
  申请人：Konradi Andrei

  公开号：US20120329807A1

  公开（公告）日：2012-12-27

  Disclosed are conjugates which bind VLA-4. Certain of these conjugates also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such conjugates are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The conjugates can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

  揭示了结合VLA-4的共轭物。其中某些共轭物还抑制白细胞粘附，特别是由VLA-4介导的白细胞粘附。这些共轭物在哺乳动物患者（例如人类）的炎症性疾病治疗中非常有用，如哮喘、阿尔茨海默病、动脉硬化、艾滋病痴呆、糖尿病、炎性肠病、类风湿性关节炎、组织移植、肿瘤转移和心肌缺血。这些共轭物也可以用于治疗多发性硬化等炎症性脑疾病。