Transformation of 5?-H-pregn-16-en-3?-ol-20-one into pregn-4-ene-9?,16?,17?-triol-3,20-dione 16,17-acetonide
摘要:
A preparative method was proposed for the preparation of pregn-4-ene-9alpha,16alpha,17alpha-triol-3,20-dione 16alpha,17alpha-acetonide (2) from 5alpha-H-pregn-16-en-3beta-ol-20-one (1). The kev stage in the proposed sequence of the reactions is the microbiological 9alpha-hydroxylation and introduction of the 4-en-3-one grouping into the molecule of 1 by R- and S-dissociative forms of the Rhodococcus sp. strain.
Transformation of 5?-H-pregn-16-en-3?-ol-20-one into pregn-4-ene-9?,16?,17?-triol-3,20-dione 16,17-acetonide
摘要:
A preparative method was proposed for the preparation of pregn-4-ene-9alpha,16alpha,17alpha-triol-3,20-dione 16alpha,17alpha-acetonide (2) from 5alpha-H-pregn-16-en-3beta-ol-20-one (1). The kev stage in the proposed sequence of the reactions is the microbiological 9alpha-hydroxylation and introduction of the 4-en-3-one grouping into the molecule of 1 by R- and S-dissociative forms of the Rhodococcus sp. strain.