ethyl 1-methyl-4-oxo-7-(4-pyridinyl-2-ylpiperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylate | 1202652-20-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: ethyl 1-methyl-4-oxo-7-(4-pyridinyl-2-ylpiperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylate
• 英文别名: Ethyl 1-methyl-4-oxo-7-(4-pyridin-2-ylpiperazin-1-yl)-1,8-naphthyridine-3-carboxylate
• CAS: 1202652-20-7
• 化学式: C₂₁H₂₃N₅O₃
• 分子量: 393.445
• InChiKey: HIYYCKBDVOYCIL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  78.9
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  ethyl 1-methyl-4-oxo-7-(4-pyridinyl-2-ylpiperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylate 在 水 、 sodium hydroxide 作用下， 反应 4.0h， 以90%的产率得到1-methyl-4-oxo-7-(4-pyridinyl-2-ylpiperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
  参考文献：
  名称：

  A 1,8-Naphthyridone Derivative Targets the HIV-1 Tat-Mediated Transcription and Potently Inhibits the HIV-1 Replication

  摘要：

  The emergence of multidrug resistant HTV-1 strains and the inability of the HAART to eradicate HIV-1 virus from infected patients demand new drugs able to interfere with an alternative step of the replicative cycle. The naphthyridone 3 (HM13N), described in the present study, is a promising anti-HIV agent due to its ability to inhibit the HIV-1 Tat-mediated transcription and the potent antiviral activity observed in acutely, chronically, and latently infected cells. The absence of any tendency to select for resistance mutations in vitro adds to the potential clinical value Of this type of compounds, especially as these compounds are drug-like and obey the Lipinski rules.

  DOI：

  10.1021/jm901211d
• 作为产物：
  描述：

  1-(2-吡啶基)哌嗪 、 ethyl 7-chloro-1-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以98%的产率得到ethyl 1-methyl-4-oxo-7-(4-pyridinyl-2-ylpiperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylate
  参考文献：
  名称：

  A 1,8-Naphthyridone Derivative Targets the HIV-1 Tat-Mediated Transcription and Potently Inhibits the HIV-1 Replication

  摘要：

  The emergence of multidrug resistant HTV-1 strains and the inability of the HAART to eradicate HIV-1 virus from infected patients demand new drugs able to interfere with an alternative step of the replicative cycle. The naphthyridone 3 (HM13N), described in the present study, is a promising anti-HIV agent due to its ability to inhibit the HIV-1 Tat-mediated transcription and the potent antiviral activity observed in acutely, chronically, and latently infected cells. The absence of any tendency to select for resistance mutations in vitro adds to the potential clinical value Of this type of compounds, especially as these compounds are drug-like and obey the Lipinski rules.

  DOI：

  10.1021/jm901211d

文献信息

• A 1,8-Naphthyridone Derivative Targets the HIV-1 Tat-Mediated Transcription and Potently Inhibits the HIV-1 Replication
  作者：Serena Massari、Dirk Daelemans、Maria Letizia Barreca、Anna Knezevich、Stefano Sabatini、Violetta Cecchetti、Alessandro Marcello、Christophe Pannecouque、Oriana Tabarrini

  DOI：10.1021/jm901211d

  日期：2010.1.28

  The emergence of multidrug resistant HTV-1 strains and the inability of the HAART to eradicate HIV-1 virus from infected patients demand new drugs able to interfere with an alternative step of the replicative cycle. The naphthyridone 3 (HM13N), described in the present study, is a promising anti-HIV agent due to its ability to inhibit the HIV-1 Tat-mediated transcription and the potent antiviral activity observed in acutely, chronically, and latently infected cells. The absence of any tendency to select for resistance mutations in vitro adds to the potential clinical value Of this type of compounds, especially as these compounds are drug-like and obey the Lipinski rules.