2-amino-5,6-dihydro-5-(4-methylphenyl)-7-phenylquinazolin-4-ol | 1206729-99-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-amino-5,6-dihydro-5-(4-methylphenyl)-7-phenylquinazolin-4-ol
• 英文别名: 2-amino-5-(4-methylphenyl)-7-phenyl-5,6-dihydro-3H-quinazolin-4-one
• CAS: 1206729-99-8
• 化学式: C₂₁H₁₉N₃O
• 分子量: 329.401
• InChiKey: ZKDIYHNNLNQXGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  67.5
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  盐酸胍 、 2-氧代-6-(4-甲基苯基)-4-苯基-3-环己烯-1-羧酸乙酯 在 sodium ethanolate 作用下， 以 乙醇 为溶剂， 以45.7%的产率得到2-amino-5,6-dihydro-5-(4-methylphenyl)-7-phenylquinazolin-4-ol
  参考文献：
  名称：

  A simple and practical method for the synthesis of 2-amino-5,6-dihydro-5,7-diarylquinazolin-4-ols

  摘要：

  Abstract magnified image We report an efficient and new method of synthesis of 2‐amino‐5,6‐dihydro‐5,7‐diarylquinazolin‐4‐ols by the reaction of substituted cyclohexenones with guanidine hydrochloride in presence of NaOEt. The reactions are with 50–72% yield. All the synthesized compounds are characterized using IR, NMR and CHN analysis. J. Heterocyclic Chem., (2009).

  DOI：

  10.1002/jhet.229

文献信息

• A simple and practical method for the synthesis of 2-amino-5,6-dihydro-5,7-diarylquinazolin-4-ols
  作者：S. Senguttuvan、Samuthira Nagarajan

  DOI：10.1002/jhet.229

  日期：2009.11

  Abstract magnified image We report an efficient and new method of synthesis of 2‐amino‐5,6‐dihydro‐5,7‐diarylquinazolin‐4‐ols by the reaction of substituted cyclohexenones with guanidine hydrochloride in presence of NaOEt. The reactions are with 50–72% yield. All the synthesized compounds are characterized using IR, NMR and CHN analysis. J. Heterocyclic Chem., (2009).