methyl 3-(2-chloro-4-(N-(t-butylacetyl)amino)benzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylate | 275383-37-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: methyl 3-(2-chloro-4-(N-(t-butylacetyl)amino)benzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylate
• 英文别名: Methyl 3-[[2-chloro-4-(3,3-dimethylbutanoylamino)phenyl]methyl]-2-methylimidazo[4,5-b]pyridine-5-carboxylate
• CAS: 275383-37-4
• 化学式: C₂₂H₂₅ClN₄O₃
• 分子量: 428.918
• InChiKey: YAOQFBNMJGMOMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  86.1
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Sulfonamide compounds and uses thereof as medicines
  申请人：Fujisawa Pharmaceutical Co. Ltd.

  公开号：US20030171396A1

  公开（公告）日：2003-09-11

  The present invention relates to a sulfonamide compound of the formula (I): 1 wherein each symbol is as defined in the specification, a salt thereof, and a pharmaceutical composition containing same. This compound can be an effective agent for the prophylaxis and treatment of the diseases curable based on a hypoglycemic action, and the diseases curable based on a cGMP-PDE inhibitory action, a smooth muscle relaxing action, a bronchodilating action, a vasodilating action, a smooth muscle cell inhibitory action and an allergy suppressing action.

  本发明涉及一种磺酰胺化合物，其化学式为(I)：1，其中每个符号在说明书中定义，其盐和含有该化合物的药物组合物。该化合物可以是一种有效的制剂，用于预防和治疗基于降糖作用可治愈的疾病，以及基于cGMP-PDE抑制作用、平滑肌松弛作用、支气管扩张作用、血管扩张作用、平滑肌细胞抑制作用和抗过敏作用可治愈的疾病。
• SULFONAMIDE COMPOUNDS AND USES THEREOF AS MEDICINES
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP1136492A1

  公开（公告）日：2001-09-26

  The present invention relates to a sulfonamide compound of the formula (I): wherein each symbol is as defined in the specification, a salt thereof, and a pharmaceutical composition containing same. This compound can be an effective agent for the prophylaxis and treatment of the diseases curable based on a hypoglycemic action, and the diseases curable based on a cGMP-PDE inhibitory action, a smooth muscle relaxing action, a bronchodilating action, a vasodilating action, a smooth muscle cell inhibitory action and an allergy suppressing action.

  本发明涉及一种式 (I) 的磺酰胺化合物： 其中各符号如说明书中所定义的磺酰胺化合物、其盐和含有该化合物的药物组合物。该化合物可作为预防和治疗基于降血糖作用的疾病和基于 cGMP-PDE 抑制作用、平滑肌松弛作用、支气管扩张作用、血管扩张作用、平滑肌细胞抑制作用和过敏抑制作用的疾病的有效药物。
• Ammonium salts of inositol hexaphosphate, and uses thereof
  申请人：——

  公开号：US20020173494A1

  公开（公告）日：2002-11-21

  The present invention comprises compounds, compositions thereof, and methods capable of delivering inositol hexaphospahte (IHP) to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells.

  本发明包括能够将肌醇六磷酸盐（IHP）输送到哺乳动物细胞的细胞质中的化合物、其组合物和方法。在某些实施方案中，本发明涉及通过向红细胞的细胞质输送 IHP 来增强哺乳动物红细胞输送氧气能力的化合物、其组合物和方法。
• US6573274B1
  申请人：——

  公开号：US6573274B1

  公开（公告）日：2003-06-03
• US6610702B2
  申请人：——

  公开号：US6610702B2

  公开（公告）日：2003-08-26