2-oxo-3-(3-phenylpropyl)-N-(tetrahydro-2H-pyran-2-yloxy)-1,2-dihydroquinoxaline-6-carboxamide | 1201916-34-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-oxo-3-(3-phenylpropyl)-N-(tetrahydro-2H-pyran-2-yloxy)-1,2-dihydroquinoxaline-6-carboxamide
• 英文别名: N-(oxan-2-yloxy)-2-oxo-3-(3-phenylpropyl)-1H-quinoxaline-6-carboxamide
• CAS: 1201916-34-8
• 化学式: C₂₃H₂₅N₃O₄
• 分子量: 407.469
• InChiKey: GYZBJXOCMXDDFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  89
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-oxo-3-(3-phenylpropyl)-N-(tetrahydro-2H-pyran-2-yloxy)-1,2-dihydroquinoxaline-6-carboxamide 在 三氟乙酸 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 10.0h， 生成 N-羟基-2-氧代-3-（3-苯基丙基）-1,2-二氢喹喔啉-6-羧酰胺
  参考文献：
  名称：

  Discovery of a New and Efficient Small Molecule for Neuronal Differentiation from Mesenchymal Stem Cell

  摘要：

  A new synthetic small molecule. compound 1, which induced a neuronal differentiation from mesenchymal stein cells (MSCs) with an excellent efficiency, was identified. Furthermore the differentiated cell by 1 showed the neural electrophysiological and cholinergic neuron properties.

  DOI：

  10.1021/jm9015558
• 作为产物：
  描述：

  O-(四氢-2H-吡喃-2-基)羟基胺 、 2-oxo-3-(3-phenylpropyl)-1,2-dihydroquinoxaline-6-carboxylic acid 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 2-oxo-3-(3-phenylpropyl)-N-(tetrahydro-2H-pyran-2-yloxy)-1,2-dihydroquinoxaline-6-carboxamide
  参考文献：
  名称：

  Discovery of a New and Efficient Small Molecule for Neuronal Differentiation from Mesenchymal Stem Cell

  摘要：

  A new synthetic small molecule. compound 1, which induced a neuronal differentiation from mesenchymal stein cells (MSCs) with an excellent efficiency, was identified. Furthermore the differentiated cell by 1 showed the neural electrophysiological and cholinergic neuron properties.

  DOI：

  10.1021/jm9015558

文献信息

• Discovery of a New and Efficient Small Molecule for Neuronal Differentiation from Mesenchymal Stem Cell
  作者：Na Ri Kim、Seung Kyu Kang、Hyun Hee Ahn、Sung Wook Kwon、Woul Seong Park、Ki Suk Kim、Sung Soo Kim、Hee Jung Jung、Sang Un Choi、Jin Hee Ahn、Kwang Rok Kim

  DOI：10.1021/jm9015558

  日期：2009.12.24

  A new synthetic small molecule. compound 1, which induced a neuronal differentiation from mesenchymal stein cells (MSCs) with an excellent efficiency, was identified. Furthermore the differentiated cell by 1 showed the neural electrophysiological and cholinergic neuron properties.