| 1192562-50-7

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 哈马拉生物碱
• CAS: 1192562-50-7
• 化学式: C₂₆H₂₇N₃O₃
• 分子量: 429.519
• InChiKey: VPMBAKNMCSCXRS-QFIPXVFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.12
• 重原子数：
  32.0
• 可旋转键数：
  3.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  65.64
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  以 水 、 异丙醇 为溶剂， 80.0 ℃ 、200.0 kPa 条件下， 以76%的产率得到
  参考文献：
  名称：

  Straightforward Synthesis of the Near-Infrared Fluorescent Voltage-Sensitive Dye RH1691 and Analogues Thereof

  摘要：

  A highly straightforward synthesis of the near-infrared voltage-sensitive dye RH1691 is reported featuring two sequential anionic additions of C-nucleophilic heterocycles on a cyanine. This convergent approach led to the synthesis of four new probes, which also exhibit fluorescence in the near-infrared region.

  DOI：

  10.1021/ol901846g

文献信息

• Traceless Synthesis of Hydantoin Fused Tetrahydro-β-carboline on Ionic Liquid Support in Green Media
  作者：Barnali Maiti、Kaushik Chanda、Chung-Ming Sun

  DOI：10.1021/ol901857h

  日期：2009.11.5

  A novel ionic liquid (IL) supported, green synthetic protocol has been developed toward the synthesis of oxo and thio hydantoin analogues tethered with tetrahydro-beta-carboline by the use of focused microwave irradiation. IL-bound tryptophan underwent a Pictet-Spengler reaction with various carbonyl compounds to generate the IL-immobilized tetrahydro-beta-carbolines in aqueous isopropanol media. Subsequent reaction of substituted tetra hydro-beta-carboline derivatives with various isocyanates and isothiocyanate provided a three-dimensional combinatorial library in a traceless fashion.