9-benzyl-7-hydro-8-oxo-2-(5-azidopentoxy)adenine | 1158841-48-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 9-benzyl-7-hydro-8-oxo-2-(5-azidopentoxy)adenine
• 英文别名: 6-amino-2-(5-azidopentoxy)-9-benzyl-7H-purin-8-one
• CAS: 1158841-48-5
• 化学式: C₁₇H₂₀N₈O₂
• 分子量: 368.398
• InChiKey: DMUNOUHMCBIRDT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  108
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  在 盐酸 、 水 作用下， 以48%的产率得到9-benzyl-7-hydro-8-oxo-2-(5-azidopentoxy)adenine
  参考文献：
  名称：

  2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation

  摘要：

  The synthesis of an array of 2-azidoalkoxy substituted 7-hydro-8-oxoadenines is described. The relation of the structure of these compounds and their ability to induce maturation of dendritic cells is evaluated. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.02.095

文献信息

• 2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation
  作者：Jimmy J. Weterings、Selina Khan、Gerbrand J. van der Heden van Noort、Cornelis J.M. Melief、Herman S. Overkleeft、Sjoerd H. van der Burg、Ferry Ossendorp、Gijsbert A. van der Marel、Dmitri V. Filippov

  DOI：10.1016/j.bmcl.2009.02.095

  日期：2009.4

  The synthesis of an array of 2-azidoalkoxy substituted 7-hydro-8-oxoadenines is described. The relation of the structure of these compounds and their ability to induce maturation of dendritic cells is evaluated. (c) 2009 Elsevier Ltd. All rights reserved.