| 1078738-83-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• CAS: 1078738-83-6
• 化学式: C₇₄H₉₄N₆O₁₂
• 分子量: 1259.59
• InChiKey: OXWBJKRFXUXQFX-WCTYBMNZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  16.06
• 重原子数：
  92.0
• 可旋转键数：
  28.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  231.06
• 氢给体数：
  4.0
• 氢受体数：
  14.0

反应信息

• 作为产物：
  描述：

  2-butoxy-N-[5-[(2-butoxy-5-formylbenzoyl)amino]-2,4-bis(2-methylpropoxy)phenyl]-5-formylbenzamide 、 5-amino-N-[5-[(5-amino-2-butoxybenzoyl)amino]-2,4-bis(2-methylpropoxy)phenyl]-2-butoxybenzamide 以 氯仿 为溶剂， 反应 15.0h， 以75%的产率得到
  参考文献：
  名称：

  Hydrogen Bonding-Directed Multicomponent Dynamic Covalent Assembly of Mono- and Bimacrocycles. Self-Sorting and Macrocycle Exchange

  摘要：

  This paper describes the multicomponent dynamic covalent assembly of macrocyclic structures by utilizing hydrogen bonding-driven zigzag anthranilamides as "leading" components. Two or three amino groups have been introduced to one side of hydrogen bonded anthranilamide oligomers. The preorganization of the frameworks enabled the amino groups to condense with structurally matched aldehydes to form mono- and bimacrocycles in good to quantitative yields. Reactions from Lip to five components have been investigated. which involved one-step formation of up to six imine bonds. The preorganization of the templates highly enhanced the stability of the macrocyclic structures. As a result, all the macrocycles Could be purified by simply recrystallizing the Crude products from suitable solvents. Coexisting experiments of three series of three to five components were also performed, which all revealed that the preorganized precursors possessed high self-sorting capacity. On the basis of the same approach, a hydrazone-based macrocycle was also prepared quantitatively, while an intermacrocycle hydrazone-imine exchange was revealed to facilitate the formation of the hydrazone-based macrocycle from an imine-based macrocycle.

  DOI：

  10.1021/jo801972s