| 1093123-17-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• CAS: 1093123-17-1
• 化学式: C₃₁H₃₅NO₅
• 分子量: 501.623
• InChiKey: COMIFBLGANZJNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  37
• 可旋转键数：
  3
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  57.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  、 氯甲酸-9-芴基甲酯 在 potassium carbonate 作用下， 以 氯仿 、 水 为溶剂， 以82%的产率得到
  参考文献：
  名称：

  Piperidine dispiro-1,2,4-trioxane analogues

  摘要：

  Dispiro N-Boc-protected 1,2,4-trioxane 2 was synthesised via Mo(acac)(2) catalysed perhydrolysis of N-Boc spirooxirane followed by condensation of the resulting beta-hydroperoxy alcohol 10 with 2-adamantanone. N-Boc 1,2,4-trioxane 2 was converted to the amine 1,2,4-trioxane hydrochloride salt 3 which was subsequently used to prepare derivatives (4-7). Several of these novel 1,2,4-trioxanes had nanomolar antimalarial activity versus the 3D7 strain of Plasmodium falciparum. Amine intermediate 3 represents a versatile derivative for the preparation of achiral arrays of trioxane analogues with antimalarial activity. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.09.052

文献信息

• Piperidine dispiro-1,2,4-trioxane analogues
  作者：Sunil Sabbani、Paul A. Stocks、Gemma L. Ellis、Jill Davies、Erik Hedenstrom、Stephen A. Ward、Paul M. O’Neill

  DOI：10.1016/j.bmcl.2008.09.052

  日期：2008.11

  Dispiro N-Boc-protected 1,2,4-trioxane 2 was synthesised via Mo(acac)(2) catalysed perhydrolysis of N-Boc spirooxirane followed by condensation of the resulting beta-hydroperoxy alcohol 10 with 2-adamantanone. N-Boc 1,2,4-trioxane 2 was converted to the amine 1,2,4-trioxane hydrochloride salt 3 which was subsequently used to prepare derivatives (4-7). Several of these novel 1,2,4-trioxanes had nanomolar antimalarial activity versus the 3D7 strain of Plasmodium falciparum. Amine intermediate 3 represents a versatile derivative for the preparation of achiral arrays of trioxane analogues with antimalarial activity. (C) 2008 Elsevier Ltd. All rights reserved.