2-(2-Tetrahydropyranyl)ethylacetat | 38786-80-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 2-(2-Tetrahydropyranyl)ethylacetat
• 英文别名: 1-acetoxy-2-tetrahydropyran-2-yl-ethane；2-tetrahydro-2H-pyran-2-ylethyl acetate；2-(oxan-2-yl)ethyl acetate
• CAS: 38786-80-0
• 化学式: C₉H₁₆O₃
• 分子量: 172.224
• InChiKey: KBSBDZLQPFBVOX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Pyridazin-3(2h)-one derivatives as pde4 inhibitors
  申请人：Dal Piaz Vittorio

  公开号：US20060052379A1

  公开（公告）日：2006-03-09

  New pyridazin-3(2H)-one derivatives having the chemical structure of general formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of phosphodiesterase 4.

  本发明公开了具有一般式(I)化学结构的新吡啶并嗪-3(2H)-酮衍生物；以及其制备过程、包含它们的制药组合物以及它们作为磷酸二酯酶4抑制剂在治疗中的应用。
• HETEROCYCLIC COMPOUND
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP2269990A1

  公开（公告）日：2011-01-05

  An object of the present invention is to provide a novel AMPA receptor potentiator. A compound represented by the following formula (I) or a salt thereof: wherein in formula (I) R1 represents (1) a halogen atom, or (2) cyano group, or the like; Ra and Rb each independently represent a hydrogen atom or C1-4 alkyl; L represents a bond, or a spacer in which the number of atoms in the main chain is 1 to 8; Ring A represents (1) a non-aromatic carbon ring of 4-8 carbon atoms, or (2) a 4- to 8-membered non-aromatic heterocycle either of which is optionally substituted with 1 or more substituents selected from (a) halogen atoms, and (b) cyano group; and Ar represents a substituted phenyl group, or optionally substituted 5- or 6-membered aromatic heterocyclic group.

  本发明的目的是提供一种新型 AMPA 受体增效剂。一种由下式（I）代表的化合物或其盐： 式（I）中 R1 代表 (1) 卤素原子，或 (2) 氰基，或类似物； Ra 和 Rb 各自独立地代表氢原子或 C1-4 烷基； L 代表键，或主链中原子数为 1 至 8 的间隔物； 环 A 代表 (1) 4-8 个碳原子的非芳香族碳环，或 (2) 4 至 8 元的非芳香族杂环 其中任一环可任选被 1 个或多个取代基取代，这些取代基选自 (a) 卤素，和 (b) 氰基；和 Ar 代表 被取代的苯基，或 任选被取代的 5 或 6 元芳香杂环基团。