作者:Liu Cai、Yu-Liang Pan、Li Chen、Jin-Pei Cheng、Xin Li
DOI:10.1039/d0cc05855f
日期:——
An efficient asymmetric allylation reaction of allylboronates with seven-membered cyclic imines, dibenzo[b,f][1,4]oxazepines, is described. The reaction, which is catalyzed by a Bi(OAc)3/CPA system, gives a range of chiral nitrogen-containing heterocycle structures in high yields and with good enantioselectivities. The conversion of these products to nitrogen-containing heterocycles is also demonstrated
Chiral Phosphoric Acid Catalyzed Asymmetric Addition of 2-(Vinyloxy)ethanol to Imines and Applications of the Products
作者:Xudong Wu、Xi Yuan、Haijun Yang、Hua Fu
DOI:10.1021/acs.orglett.9b01970
日期:2019.7.5
Chiral nitrogen-containing molecules such as chiral amines, azetidines, and 2-substituted tetrahydroquinolines are important privileged scaffolds in medicinal chemistry. In this paper, an efficient and highly enantioselective chiralphosphoricacidcatalyzed asymmetric addition of 2-(vinyloxy)ethanol to imines has been developed for the first time, providing the corresponding chiral amines containing
Microwave-Assisted Synthesis of Substituted Dibenzo[<i>b</i>,<i>f</i>][1,4]thiazepines, Dibenzo[<i>b</i>,<i>f</i>][1,4]oxazepines, Benzothiazoles, and Benzimidazoles
作者:Yu-Chin Lin、Ni-Ching Li、Yie-Jia Cherng
DOI:10.1002/jhet.2003
日期:2014.5
A highly efficient synthesis for possessing 7‐membered rings with two heteroatoms is described, using efficient microwave‐assisted one‐pot method to synthesize (substituted) dibenzo[b,f][1,4]thiazepines [1] and dibenzo[b,f][1,4]oxazepines [2] in high yields (up to 99%) by cyclocondensations of o‐aminothiophenol or o‐aminophenol with o‐halobenzaldehydes, o‐fluoroacetophenone, and o‐fluorobenzophenone
利用高效的微波辅助一锅法合成(取代的)二苯并[ b,f ] [1,4]噻氮平[1]和二苯并[ b ],描述了一种具有两个杂原子的7元环的高效合成方法。通过邻氨基硫酚或邻氨基苯酚与邻卤代苯甲醛,邻氟苯乙酮和邻氟二苯甲酮的环缩合,高产率(高达99%)的f ] [1,4]氧杂氮杂[2] 。在没有碱的情况下,邻氨基苯硫酚与邻卤代苯甲醛反应生成苯并噻唑。
Stereoselective Oxidative Mannich Reaction of Ketones with Dihydrodibenzo‐Oxazepines via a Merger of Photoredox‐/Electro‐Catalysis with Organocatalysis
Goodbye Tear Gas: The merger of Proline catalysis with organic photoredoxcatalysis or electrocatalysis provides an alternative strategy for synthesizing enantioenriched dihydrodibenzo[b,f][1,4]oxazepine derivatives by eliminating the direct use of toxic CR gas. Good yields and excellent stereoselectivities have been achieved under mild reaction conditions involving abundant and green sources.
[4+2] Annulation of arylmethylphosphonochloridates with dibenzo[<i>b</i>,<i>f</i>][1,4]oxazepines: a practical approach to polycyclic benzo-δ-phosphonolactams
作者:Xin Yuan、Yelong Lei、Zhicheng Fu、Jiaxi Xu
DOI:10.1039/d2nj05558a
日期:——
A novel and transition metal-free synthesis of benzo-δ-phosphonolactams from readily available ethyl arylmethylphosphonochloridates and dibenzo[b,f][1,4]oxazepines was developed. The reaction includes tandem phosphonylation, deprotonation, intramolecular nucleophilic addition, and aromatization, affording various polycyclic benzo-δ-phosphonolactams in moderate to good yields and diasteroselectivity
从现成的乙基芳基甲基膦酰氯和二苯并 [ b , f ][1,4]oxazepine 开发了一种新的无过渡金属合成苯并-δ-膦内酰胺。该反应包括串联膦酰化、去质子化、分子内亲核加成和芳构化,以中等至良好的产率和一锅法的非对映选择性(高达 96% 的产率和 83:17 dr)提供各种多环苯并-δ-膦内酰胺。