[(1S,2S,3R,4S,7R,9S,10S,12R)-4,12-diacetyloxy-1-hydroxy-10,14,17,17-tetramethyl-11,15-dioxo-9-triethylsilyloxy-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] naphthalene-1-carboxylate | 163352-11-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: [(1S,2S,3R,4S,7R,9S,10S,12R)-4,12-diacetyloxy-1-hydroxy-10,14,17,17-tetramethyl-11,15-dioxo-9-triethylsilyloxy-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] naphthalene-1-carboxylate
• CAS: 163352-11-2
• 化学式: C₄₁H₅₂O₁₁Si
• 分子量: 748.943
• InChiKey: AQXOQWURZPXHEI-DHWWQEJOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.04
• 重原子数：
  53.0
• 可旋转键数：
  9.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  151.73
• 氢给体数：
  1.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  [(1S,2S,3R,4S,7R,9S,10S,12R)-4,12-diacetyloxy-1-hydroxy-10,14,17,17-tetramethyl-11,15-dioxo-9-triethylsilyloxy-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] naphthalene-1-carboxylate 在 sodium tetrahydroborate 、 sodium hexamethyldisilazane 、 氟化氢吡啶 作用下， 以 甲醇 为溶剂， 生成 [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] naphthalene-1-carboxylate
  参考文献：
  名称：

  Nicolaou, Kyriacos Costa; Couladouros, E. A.; Nantermet, P. G., Angewandte Chemie, 1994, vol. 106, # 15/16, p. 1669 - 1671

  摘要：

  DOI：
• 作为产物：
  描述：

  naphthalen-1-yl-lithium 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 0.17h， 生成 [(1S,2S,3R,4S,7R,9S,10S,12R)-4,12-diacetyloxy-1-hydroxy-10,14,17,17-tetramethyl-11,15-dioxo-9-triethylsilyloxy-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] naphthalene-1-carboxylate
  参考文献：
  名称：

  Nicolaou, Kyriacos Costa; Couladouros, E. A.; Nantermet, P. G., Angewandte Chemie, 1994, vol. 106, # 15/16, p. 1669 - 1671

  摘要：

  DOI：

文献信息

• Chemical Synthesis and Biological Evaluation of C-2 Taxoids
  作者：K. C. Nicolaou、J. Renaud、P. G. Nantermet、E. A. Couladouros、R. K. Guy、W. Wrasidlo

  DOI：10.1021/ja00114a005

  日期：1995.3

  An efficient, general method for the synthesis of 1,2-hydroxy esters by regioselective nucleophilic opening of 1,2-cyclic carbonate systems has been developed. A reliable and practical route giving access to the taxoid carbonate 2 from the readily available 10-deacetylbaccatin III (13) has been established. Nucleophilic opening of the carbonate 2 with a variety of nucleophiles provided a number of novel C-2 Taxols. Water-soluble taxoid onium salts (e.g., 31e, 31n, 32, and 34b) were also synthesized and studied. A selected number of taxoids were subjected to cytotoxicity and tubulin polymerization assays as well as in vivo studies. The results of these studies are reported herein.