tetrahydrocortisol | 95908-57-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: tetrahydrocortisol
• 英文别名: 2-hydroxy-1-[(3R,8S,9S,10S,11S,13S,14S,17R)-3,11,17-trihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-yl]ethanone
• CAS: 95908-57-9
• 化学式: C₂₁H₃₄O₅
• 分子量: 366.498
• InChiKey: AODPIQQILQLWGS-RQERNRIFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• METHODS FOR THE PURIFICATION OF DEOXYCHOLIC ACID
  申请人：Moriarty Robert M.

  公开号：US20130137884A1

  公开（公告）日：2013-05-30

  Synthetic methods for preparing deoxycholic acid and intermediates thereof, high purity synthetic deoxycholic acid, compositions and methods of use are provided. Also, provided are processes for the synthesis of 12-keto or 12-α-hydroxy-steroids from Δ-9,11-ene, 11-keto or 11-hydroxy-β-steroids. This invention is also directed to novel compounds prepared during the synthesis. This invention is also directed to the synthesis of deoxycholic acid starting from hydrocortisone.

  提供了用于制备去氧胆酸及其中间体的合成方法，高纯度合成去氧胆酸，以及使用的组合物和方法。还提供了从 Δ-9,11-烯基，11-酮基或11-羟基-β-类固醇合成12-酮基或12-α-羟基类固醇的方法。本发明还涉及在合成过程中制备的新化合物。本发明还涉及从氢化可的松开始合成去氧胆酸的方法。
• [EN] METHODS FOR THE PURIFICATION OF DEOXYCHOLIC ACID<br/>[FR] PROCÉDÉS POUR LA PURIFICATION DE L'ACIDE DÉSOXYCHOLIQUE
  申请人：KYTHERA BIOPHARMACEUTICALS INC

  公开号：WO2011075701A2

  公开（公告）日：2011-06-23

  Synthetic methods for preparing deoxycholic acid and intermediates thereof, high purity synthetic deoxycholic acid, compositions and methods of use are provided. Also, provided are processes for the synthesis of 12-keto or 12-α-hydroxysteroids from Δ-9,11-ene, 11-keto or 11-hydroxy-β-steroids. This invention is also directed to novel compounds prepared during the synthesis. This invention is also directed to the synthesis of deoxycholic acid starting from hydrocortisone.

  本发明提供了制备去氧胆酸及其中间体的合成方法，高纯度合成去氧胆酸，以及使用的组合物和方法。还提供了从Δ-9,11-ene，11-keto或11-hydroxy-β-steroids合成12-keto或12-α-hydroxysteroids的过程。本发明还涉及在合成过程中制备的新化合物。本发明还涉及从氢化可的松开始合成去氧胆酸的方法。
• Stable immunochemical assay reagent for the determination of haptens, and assay method using said reagent
  申请人：TEIKOKU HORMONE MFG. CO., LTD.

  公开号：EP0010405A1

  公开（公告）日：1980-04-30

  Immunochemical assay reagents comprising combinations of (A) a carboxyl-containing water-soluble mono-olefinic polymeric compound combined with a hapten or a chemically modified product thereof, or a hapten-supported latex resulting from the chemical linking of the hapten-bound polymeric compound to a polymeric latex, with (B) a hapten antibody, or a hapten antibody-supported carrier; and a method for immunochemically determining haptens using the assay reagent. The assay reagent is very stable and can be stored for an extended period of time without degradation. Transition from an agglutination inhibited pattern to an agglutinated pattern can be discerned clearly and rapidly with high sensitivity when using the assay reagent.

  免疫化学检测试剂，包括(A)含羧基的水溶性单烯烃聚合物化合物与合蛋白或其化学修饰产物的组合，或合蛋白结合的聚合物化合物与聚合物胶乳化学连接产生的合蛋白支持的胶乳，与(B)合蛋白抗体或合蛋白抗体支持的载体的组合；以及使用该检测试剂对合蛋白进行免疫化学测定的方法。该检测试剂非常稳定，可长期保存而不会降解。使用该检测试剂时，从凝集抑制模式到凝集模式的转变可以清晰、快速、高灵敏度地分辨出来。
• PURIFIED DEOXYCHOLIC ACID AND ITS COSMETIC USE IN THE NON-SURGICAL REMOVAL OF UNDESIRABLE FAT DEPOSITS
  申请人：Kythera Biopharmaceuticals, Inc.

  公开号：EP3040342A1

  公开（公告）日：2016-07-06

  Compositions of deoxycholic acid (DCA) containing a steroidal DCA precursor or by-product containing a 12.beta.-hydroxy group (in particular 12.beta.-DCA) and their use in a cosmetic method of non-surgical removal of undesirable fat deposits.

  含有甾体 DCA 前体或含有 12.β.-羟基（尤其是 12.β.-DCA）的副产品的脱氧胆酸（DCA）组合物及其在非手术去除不良脂肪沉积的美容方法中的用途。
• Methods for the purification of deoxycholic acid
  申请人：Kythera Biopharmaceuticals, Inc.

  公开号：US10005813B2

  公开（公告）日：2018-06-26

  Synthetic methods for preparing deoxycholic acid and intermediates thereof, high purity synthetic deoxycholic acid, compositions and methods of use are provided. Also, provided are processes for the synthesis of 12-keto or 12-α-hydroxysteroids from Δ-9,11-ene, 11-keto or 11-hydroxy-β-steroids. This invention is also directed to novel compounds prepared during the synthesis. This invention is also directed to the synthesis of deoxycholic acid starting from hydrocortisone.

  提供了制备脱氧胆酸及其中间体的合成方法、高纯度合成脱氧胆酸、组合物和使用方法。此外，还提供了从Δ-9,11-烯、11-酮或 11-羟基-β-类固醇合成 12-酮或 12-α-羟基类固醇的工艺。本发明还涉及在合成过程中制备的新型化合物。本发明还涉及从氢化可的松开始合成脱氧胆酸。