6-(6-(3-aminophenyl)-1H-indol-1-yl)-N-(2-morpholinoethyl)pyrimidin-4-amine | 1298084-43-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 6-(6-(3-aminophenyl)-1H-indol-1-yl)-N-(2-morpholinoethyl)pyrimidin-4-amine
• 英文别名: 6-[6-(3-aminophenyl)indol-1-yl]-N-(2-morpholin-4-ylethyl)pyrimidin-4-amine
• CAS: 1298084-43-1
• 化学式: C₂₄H₂₆N₆O
• 分子量: 414.51
• InChiKey: OKYFCWUHENLYRH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  81.2
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• NOVEL 1,6-DISUBSTITUTED INDOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS
  申请人：Sim Tae Bo

  公开号：US20120271048A1

  公开（公告）日：2012-10-25

  Disclosed are a 1,6-substituted indole compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention and treatment of cancers caused by abnormal cell growth comprising the compound as an effective ingredient. Since the novel indole compound exhibits superior inhibition activity against various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating cancers caused by abnormal cell growth.

  公开了一种具有蛋白激酶抑制活性的1,6-取代吲哚化合物，其包括一种药用可接受的盐和一种药物组合物，用于预防和治疗由异常细胞生长引起的癌症，其中该化合物作为有效成分。由于这种新型吲哚化合物表现出对参与生长因子信号转导的各种蛋白激酶具有优越的抑制活性，因此它可用作预防或治疗由异常细胞生长引起的癌症的药物。
• US8765749B2
  申请人：——

  公开号：US8765749B2

  公开（公告）日：2014-07-01
• [EN] NOVEL 1,6-DISUBSTITUTED INDOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS<br/>[FR] NOUVEAUX COMPOSÉS D'INDOLE 1,6-DISUBSTITUÉS UTILISÉS EN TANT QU'INHIBITEURS DES PROTÉINES KINASES
  申请人：KOREA INST SCI & TECH

  公开号：WO2011052923A2

  公开（公告）日：2011-05-05

  Disclosed are a 1,6-substituted indole compound having a protein kinase inhibition activity, a pharmaceutically acceptable salt, and a pharmaceutical composition for prevention and treatment of cancers caused by abnormal cell growth comprising the compound as an effective ingredient. Since the novel indole compound exhibits superior inhibition activity against various protein kinases involved in growth factor signal transduction, it is useful as an agent for preventing or treating cancers caused by abnormal cell growth.