5-(methylthio)-2'-deoxyuridine | 14985-32-1

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 5-(methylthio)-2'-deoxyuridine
• 英文别名: 5-Methylmercapto-2'-deoxyuridine；5-methylsulfanyl-2'-deoxy-uridine；1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylsulfanylpyrimidine-2,4-dione
• CAS: 14985-32-1
• 化学式: C₁₀H₁₄N₂O₅S
• 分子量: 274.298
• InChiKey: NQJYWLBQAUXGGI-SHYZEUOFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  124
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Novel Compounds and Derivatizations of DNAs and RNAs on the Nucleobases of Pyrimidines for Function, Structure and Therapeutics
  申请人：Huang Zhen

  公开号：US20120070825A1

  公开（公告）日：2012-03-22

  Disclosed are compounds of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer. Also disclosed are methods of preparing compound of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer. Further disclosed are methods of conducting drug discovery and research comprises applying the compound of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer in an investigation.

  本发明涉及公式（I）的化合物，其衍生物或互变异构体，或该化合物或该互变异构体的药学上可接受的盐。本发明还涉及制备公式（I）的化合物，其衍生物或互变异构体，或该化合物或该互变异构体的药学上可接受的盐的方法。本发明还涉及应用公式（I）的化合物，其衍生物或互变异构体，或该化合物或该互变异构体的药学上可接受的盐，在药物发现和研究中进行研究的方法。
• US8809357B2
  申请人：——

  公开号：US8809357B2

  公开（公告）日：2014-08-19
• [EN] NOVEL COMPOUNDS AND DERIVATIZATION OF DNAS AND RNAS ON THE NUCLEOBASES OF PYRIMIDINES FOR FUNCTION, STRUCTURE, AND THERAPEUTICS<br/>[FR] NOUVEAUX COMPOSÉS ET DÉRIVATION D'ADN ET D'ARN SUR LES NUCLÉOBASES DE PYRIMIDINES À DES FINS DE FONCTION, DE STRUCTURE ET DE THÉRAPEUTIQUE
  申请人：SENA RES INC

  公开号：WO2010135564A2

  公开（公告）日：2010-11-25

  Disclosed are compounds of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer. Also disclosed are methods of preparing compound of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer. Further disclosed are methods of counducting drug discovery and research comprises applying the compound of formula (I), a derivative, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer in an investigation.