{(R)-6-[2-(4-Chloro-phenyl)-ethyl]-1,2,3,4-tetrahydro-naphthalen-2-yl}-dipropyl-amine | 175556-11-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: {(R)-6-[2-(4-Chloro-phenyl)-ethyl]-1,2,3,4-tetrahydro-naphthalen-2-yl}-dipropyl-amine
• 英文别名: 2-Naphthalenamine, 6-[2-(4-chlorophenyl)ethyl]-1,2,3,4-tetrahydro-N,N-dipropyl-, (R)-；(2R)-6-[2-(4-chlorophenyl)ethyl]-N,N-dipropyl-1,2,3,4-tetrahydronaphthalen-2-amine
• CAS: 175556-11-3
• 化学式: C₂₄H₃₂ClN
• 分子量: 369.978
• InChiKey: XJCNAPNYTSUCIR-XMMPIXPASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  丙醛 、 {(R)-6-[(E)-2-(4-Chloro-phenyl)-vinyl]-1,2,3,4-tetrahydro-naphthalen-2-yl}-((S)-1-phenyl-ethyl)-propyl-amine 在 palladium on activated charcoal 甲酸铵 、 三乙酰氧基硼氢化钠 、 溶剂黄146 作用下， 生成 {(R)-6-[2-(4-Chloro-phenyl)-ethyl]-1,2,3,4-tetrahydro-naphthalen-2-yl}-dipropyl-amine
  参考文献：
  名称：

  Novel 6-substituted 2-aminotetralins with potent and selective affinity for the dopamine D3 receptor

  摘要：

  Starting from (1S,2R)-5-methoxy-1-methyl-2-N,N-dipropylaminotetralin [(+)-UH-232] as a lead structure, a series of novel 6-substituted 2-aminotetralins have been discovered which show high affinity for dopamine D-3 receptors. One compound, GR218231, exhibits ca. 400 fold selectivity for the dopamine D-3 receptor over the D-2 receptor and ca. 10,000 fold selectivity with respect to D-1 and D-4 receptors.

  DOI：

  10.1016/0960-894x(96)00043-1

文献信息

• Novel 6-substituted 2-aminotetralins with potent and selective affinity for the dopamine D3 receptor
  作者：P.J. Murray、R.M. Helden、M.R. Johnson、G.M. Robertson、D.I.C. Scopes、M. Stokes、S. Wadman、J.W.F. Whitehead、A.G. Hayes、G.J. Kilpatrick、C. Large、C.M. Stubbs、M.P. Turpin

  DOI：10.1016/0960-894x(96)00043-1

  日期：1996.2

  Starting from (1S,2R)-5-methoxy-1-methyl-2-N,N-dipropylaminotetralin [(+)-UH-232] as a lead structure, a series of novel 6-substituted 2-aminotetralins have been discovered which show high affinity for dopamine D-3 receptors. One compound, GR218231, exhibits ca. 400 fold selectivity for the dopamine D-3 receptor over the D-2 receptor and ca. 10,000 fold selectivity with respect to D-1 and D-4 receptors.