O-ethyl S-(1-cyanoethyl) xanthate | 72775-21-4

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫代缩醛
• 英文名称: O-ethyl S-(1-cyanoethyl) xanthate
• 英文别名: O-ethyl 1-cyanoethylsulfanylmethanethioate
• CAS: 72775-21-4
• 化学式: C₆H₉NOS₂
• 分子量: 175.276
• InChiKey: UCJIVOSVXDEWAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  90.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-甲基戊醛 、 O-ethyl S-(1-cyanoethyl) xanthate 在 sodium hydroxide 、 甲基三辛基氯化铵 作用下， 生成 (E)-2,4-Dimethyl-hept-2-enenitrile
  参考文献：
  名称：

  A New and Facile Synthesis of 2-Alkenenitriles from Carbonyl Compounds

  摘要：

  DOI：

  10.1055/s-1979-28863

文献信息

• Xanthate-mediated intermolecular alkylation of pyrazines
  作者：Qi Huang、Ling Qin、Samir Z. Zard

  DOI：10.1016/j.tet.2018.08.040

  日期：2018.10

  An expedient approach for the intermolecular C-H functionalization of pyrazines and other heteroarenes by the radical chemistry of xanthates is reported. Incorporation of a multitude of functional alkyl groups onto these heteroarenes proceeds in good yield and good to excellent regioselectivity, leading to highly functionalized heteroaromatics.

  报道了通过黄药的自由基化学对吡嗪和其他杂芳烃进行分子间CH官能化的简便方法。在这些杂芳烃上并入大量官能烷基的产率高并且区域选择性好至极好，从而导致高度官能化的杂芳族化合物。
• A convergent route to structures with multiple contiguous carbon–nitrogen bonds. The divergent role of N-acyl groups
  作者：Songzhe Han、Samir Z. Zard

  DOI：10.1016/j.tet.2016.05.085

  日期：2016.12

  to N,N-diacetyl imidazol-2-one can be followed by a second addition to N,N-di-Boc imidazol-2-one to give after reductive dexanthylation a protected tetra-amine possessing four contiguous carbon–nitrogen bonds, or even five if the starting xanthate itself bears a protected amine. The success of this sequence hinges on the difference in radical stability between radicals substituted by an N-acyl and

  将黄原酸酯自由基加成到N，N-二乙酰基咪唑-2-酮上，然后第二加成N，N-二-乙酰基咪唑-2-酮，在还原性右胸腺嘧啶化后得到具有四个连续碳的受保护的四胺。 -氮键，或者如果起始黄药本身带有受保护的胺，则为五个。该序列的成功取决于被N-酰基和N-氨基甲酰基氮取代的基团之间的基团稳定性的差异，这可以控制基团的添加并防止低聚物的形成。
• Ophthalmic devices
  申请人：Bausch & Lomb Incorporated

  公开号：US10668676B2

  公开（公告）日：2020-06-02

  An ophthalmic device is disclosed that is a polymerization product of a monomeric mixture comprising: (a) a major amount of one or more non-silicone-containing hydrophilic monomers; (b) a crosslinking agent mixture comprising (i) one or more first crosslinking agents containing at least two ethylenically unsaturated reactive end groups, wherein the at least two ethylenically unsaturated reactive end groups are (meth)acrylate-containing reactive end groups and (ii) one or more second crosslinking agents containing at least two ethylenically unsaturated reactive end groups wherein at least one of the ethylenically unsaturated reactive end groups is a non-(meth)acrylate reactive end group, and (c) one or more hydrophilic polymers or copolymers comprising one or more hydrophilic units and a thio carbonyl thio fragment of a reversible addition fragmentation chain transfer (“RAFT”) agent wherein the ophthalmic device has an equilibrium water content of at least about 45 weight percent.

  本发明公开了一种眼科设备，它是一种单体混合物的聚合产物，该单体混合物包括(a) 一种或多种主要量的非含硅亲水单体；(b) 交联剂混合物，包括(i)一种或多种含有至少两个乙烯不饱和反应性末端基团的第一交联剂，其中至少两个乙烯不饱和反应性末端基团为含(甲基)丙烯酸酯反应性末端基团；(ii)一种或多种含有至少两个乙烯不饱和反应性末端基团的第二交联剂，其中至少一个乙烯不饱和反应性末端基团为非(甲基)丙烯酸酯反应性末端基团、(c) 一种或多种亲水聚合物或共聚物，包含一种或多种亲水单元和可逆加成片段链转移 （"RAFT"）剂的硫代羰基硫代片段，其中眼科装置的平衡水含量至少为约 45 重量百分 比。
• TANAKA KAZUHIKO; ONO NOBORU; KUBO YOSHIHIRO; KAJI ARITSUNE, SYNTHESIS, 1979, NO 11, 890-891
  作者：TANAKA KAZUHIKO、 ONO NOBORU、 KUBO YOSHIHIRO、 KAJI ARITSUNE

  DOI：——

  日期：——
• OPHTHALMIC DEVICES
  申请人：Bausch & Lomb Incorporated

  公开号：US20200047437A1

  公开（公告）日：2020-02-13

  An ophthalmic device is disclosed that is a polymerization product of a monomeric mixture comprising: (a) a major amount of one or more non-silicone-containing hydrophilic monomers; (b) a crosslinking agent mixture comprising (i) one or more first crosslinking agents containing at least two ethylenically unsaturated reactive end groups, wherein the at least two ethylenically unsaturated reactive end groups are (meth)acrylate-containing reactive end groups and (ii) one or more second crosslinking agents containing at least two ethylenically unsaturated reactive end groups wherein at least one of the ethylenically unsaturated reactive end groups is a non-(meth)acrylate reactive end group, and (c) one or more hydrophilic polymers or copolymers comprising one or more hydrophilic units and a thio carbonyl thio fragment of a reversible addition fragmentation chain transfer (“RAFT”) agent wherein the ophthalmic device has an equilibrium water content of at least about 45 weight percent.