3-heptanoyl-1-methyl-4-phenyl-1-azaspiro[4.5]deca-3,6,9-triene-2,8-dione | 1607433-29-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 3-heptanoyl-1-methyl-4-phenyl-1-azaspiro[4.5]deca-3,6,9-triene-2,8-dione
• CAS: 1607433-29-3
• 化学式: C₂₃H₂₅NO₃
• 分子量: 363.456
• InChiKey: LYPQOZDTMGBDAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.89
• 重原子数：
  27.0
• 可旋转键数：
  7.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  54.45
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  庚醛 、 N-methyl-N,3-diphenylprop-2-ynamide 在 叔丁基过氧化氢 作用下， 以 乙酸丁酯 为溶剂， 反应 36.0h， 以78%的产率得到3-heptanoyl-1-methyl-4-phenyl-1-azaspiro[4.5]deca-3,6,9-triene-2,8-dione
  参考文献：
  名称：

  Metal-Free Oxidative Ipso-Carboacylation of Alkynes: Synthesis of 3-Acylspiro[4,5]trienones from N-Arylpropiolamides and Aldehydes

  摘要：

  A general and metal-free radical route to synthesis of 3-acylspiro[4,5]trienones is established that utilizes TBHP (tert-butyl hydrogenperwdde) as an oxidation and a reaction partner to trigger the oxidative ipso-carboacylation of N-arylpropiolamides with aldehydes. This method offers a new difunctionalization of alkynes through oxidative cross coupling of the aldehyde C(sp(2))-H bond with an ipso-aromatic carbon.

  DOI：

  10.1021/jo5005982

文献信息

• Ag-Catalyzed Oxidative <i>ipso</i>-Cyclization via Decarboxylative Acylation/Alkylation: Access to 3-Acyl/Alkyl-spiro[4.5]trienones
  作者：Chada Raji Reddy、Dattahari H. Kolgave、Muppidi Subbarao、Mounika Aila、Santosh Kumar Prajapti

  DOI：10.1021/acs.orglett.0c01588

  日期：2020.7.17

  A strategy to functionalized spiro[4.5]trienones, by domino silver-catalyzed decarboxylative acylation or alkylation/ ipso-cyclization of N-arylpropiolamides with α-keto acids/alkyl carboxylic acids, is presented. This transformation offers a wide range of substituted 3-acyl/alkyl-spiro[4.5]trienones in high yields with a broad substrate scope. The approach was further extended to access fused tricyclic

  的策略官能螺[4.5] trienones，通过多米诺银催化的脱羧酰化或烷基化/烷基本位的-cyclization Ñ与-arylpropiolamidesα酮酸/烷基羧酸，被呈现。该转化以高收率和广泛的底物范围提供了广泛的取代的3-酰基/烷基-螺[4.5]三烯酮。该方法进一步延长到接入稠合三环框架，6,7-二氢-3- ħ吡咯并[2,1- Ĵ ]喹啉-3,9-（5 ħ） -二酮。