5-isopropylidene-4-methoxy-5H-furan-2-one | 860416-69-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: 5-isopropylidene-4-methoxy-5H-furan-2-one
• 英文别名: 5-isopropylidene-4-methoxy-5H-furan-2-one；5-Isopropyliden-4-methoxy-5H-furan-2-on
• CAS: 860416-69-9
• 化学式: C₈H₁₀O₃
• 分子量: 154.166
• InChiKey: LQSVPINSZZXPEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.37
• 重原子数：
  11.0
• 可旋转键数：
  1.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  35.53
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  5-isopropylidene-4-methoxy-5H-furan-2-one 在 sodium hydroxide 作用下， 生成 3-methoxy-5-methyl-4-oxo-hex-2-enoic acid
  参考文献：
  名称：

  155.与青霉素有关的化合物。第二部分 二氢杨酸的合成

  摘要：

  DOI：

  10.1039/jr9470000805
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 甲醇 、 ammonium hydroxide 作用下， 生成 5-isopropylidene-4-methoxy-5H-furan-2-one
  参考文献：
  名称：

  155.与青霉素有关的化合物。第二部分 二氢杨酸的合成

  摘要：

  DOI：

  10.1039/jr9470000805

文献信息

• Detecting nurse‐perceived patient treatment difficulty of psychiatric patients in hospital: an evaluation of a patient assessment sheet
  作者：R. F. Chiovitti、R. Gallop

  DOI：10.1046/j.1365-2850.2000.00285.x

  日期：2000.6

  Many changes have occurred in hospital psychiatric care, including decreased length of hospital stay and increased patient acuity. These changes highlight the need for nurses to adequately assess and formally document patient treatment difficulties. The purposes of this study were to determine the ability of the Patient Assessment Sheet (PAS) to predict patient ‘problems’ that psychiatric nurses perceived as associated with patient treatment difficulty, and to identify the patient problems missing from the PAS. These purposes were accomplished by comparing the PAS to the Hospital Treatment Rating Scales (HTRS). A correlational design and multiple linear regression technique were used. Eight psychiatric registered nurses assessed a total of 110 patients, admitted consecutively to one inpatient psychiatric unit. The HTRS and the PAS were used independently for each patient. Four PAS items (active affect, passive affect, aggression toward self, and patient confusion) significantly predicted 38% of the variance from the HTRS; and three HTRS items (isolation and withdrawal from relationships, noninvolvement in treatment, and wide variability in mood) significantly predicted 22% of the residual variance from the HTRS. The identified PAS and HTRS items help to make visible patient problems associated with nurse‐perceived patient treatment difficulty. This identification is potentially important for both clinical and political purposes.