| 461677-76-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• CAS: 461677-76-9
• 化学式: C₄₁H₅₈N₁₂O₁₄
• 分子量: 942.984
• InChiKey: JAUSKAYTOQZHAC-XNMGBQRESA-N

反应信息

• 作为反应物：
  描述：

  在 盐酸 作用下， 反应 4.0h， 以17 mg的产率得到(3S,6R,9S,12R,15S)-12-(4-Hydroxy-benzyl)-6,9-bis-[(S)-hydroxy-((S)-2-imino-imidazolidin-4-yl)-methyl]-3-hydroxymethyl-15-((S)-1-phenyl-ethyl)-1,4,7,10,13,16-hexaaza-cyclooctadecane-2,5,8,11,14,17-hexaone
  参考文献：
  名称：

  Mannopeptimycins, Novel Antibacterial Glycopeptides from Streptomyces hygroscopicus, LL-AC98

  摘要：

  A series of novel antibiotics with activity against methicillin-resistant staphylococci and vancomycin-resistant enterococci has been purified, and their structures have been characterized using spectroscopic analyses and chemical conversions. These antibiotics, designated mannopeptimycins alpha-epsilon (1-5), are glycosylated cyclic hexapeptides Containing two stereoisomers of an unprecedented amino acid, alpha-amino-beta-[4'-(2'-iminoimidazolidinyl)]-beta-hydroxypropionic acid (Aiha), as a distinguishing feature. The cyclic peptide core of these antibiotics is attached to a mannosyl monosaccharide moiety in 2 and to mannosyl monosaccharide and disaccharide moieties in 1, 3, 4, and 5. The presence and position of an isovaleryl group in the terminal mannose (Man-B) in 3-5 are critical for retaining antibacterial potency.

  DOI：

  10.1021/ja020257s
• 作为产物：
  描述：

  在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以43 mg的产率得到
  参考文献：
  名称：

  Mannopeptimycins, Novel Antibacterial Glycopeptides from Streptomyces hygroscopicus, LL-AC98

  摘要：

  A series of novel antibiotics with activity against methicillin-resistant staphylococci and vancomycin-resistant enterococci has been purified, and their structures have been characterized using spectroscopic analyses and chemical conversions. These antibiotics, designated mannopeptimycins alpha-epsilon (1-5), are glycosylated cyclic hexapeptides Containing two stereoisomers of an unprecedented amino acid, alpha-amino-beta-[4'-(2'-iminoimidazolidinyl)]-beta-hydroxypropionic acid (Aiha), as a distinguishing feature. The cyclic peptide core of these antibiotics is attached to a mannosyl monosaccharide moiety in 2 and to mannosyl monosaccharide and disaccharide moieties in 1, 3, 4, and 5. The presence and position of an isovaleryl group in the terminal mannose (Man-B) in 3-5 are critical for retaining antibacterial potency.

  DOI：

  10.1021/ja020257s