1-Methylisoindol | 72590-68-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 1-Methylisoindol
• 英文别名: 1-Methyl-isoindole；1-methyl-2H-isoindole
• CAS: 72590-68-2
• 化学式: C₉H₉N
• mdl: MFCD19221894
• 分子量: 131.177
• InChiKey: RUIAUVYVCXIZFV-UHFFFAOYSA-N

物化性质

• 沸点：
  284.1±9.0 °C(Predicted)
• 密度：
  1?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.111
• 拓扑面积：
  15.8
• 氢给体数：
  1
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1-Methylisoindol 、 N-苯基马来酰亚胺 以51%的产率得到
  参考文献：
  名称：

  CHACKO E.; BORNSTEIN J.; SARDELLA D. J., TETRAHEDRON, 1979, 35, NO 9, 1055-1058

  摘要：

  DOI：

文献信息

• KINASE INHIBITORS
  申请人：CHIESI FARMACEUTICI S.p.A.

  公开号：US20140364411A1

  公开（公告）日：2014-12-11

  Compounds of formula (I) described herein are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

  本文描述的化合物的化学式（I）是p38 MAPK抑制剂，可用作抗炎药物，用于治疗呼吸道疾病等疾病。
• [EN] MORPHOLINO COMPOUNDS, USES AND METHODS<br/>[FR] COMPOSÉS MORPHOLINO, UTILISATIONS ET PROCÉDÉS
  申请人：UNIV DUNDEE

  公开号：WO2012160392A1

  公开（公告）日：2012-11-29

  The invention relates to morpholino-derivatives according to Formula (I) or stereoisomers or pharmaceutically acceptable salts or solvate thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, m and n are as defined in the specification. The compounds are antagonists, reverse agonists or agonists of G-protein coupled receptors, such as dopamine D4 and 5HT1a. The inventions also relates to pharmaceutical compositions comprising the compounds and methods involving the compounds and compositions. The compounds and compositions of the invention may in particular be used in the treatment of diseases and disorders, such as neurological and neurodegenerative diseases; or as lead compounds for the design and selection of further therapeutic compounds.

  该发明涉及根据式（I）的吗啡啉衍生物或其立体异构体或药用可接受的盐或溶剂化物，其中R1、R2、R3、R4、R5、R6、R7、R8、R9、m和n如规范中定义。这些化合物是G蛋白偶联受体的拮抗剂、逆向激动剂或激动剂，例如多巴胺D4和5HT1a。该发明还涉及包括这些化合物的药物组合物和涉及这些化合物和组合物的方法。该发明的化合物和组合物特别可用于治疗疾病和疾病，如神经和神经退行性疾病；或作为设计和选择更多治疗化合物的引导化合物。
• MORPHOLINO COMPOUNDS, USES AND METHODS
  申请人：University of Dundee

  公开号：US20140148452A1

  公开（公告）日：2014-05-29

  The invention relates to morpholino-derivatives according to Formula (I) or stereoisomers or pharmaceutically acceptable salts or solvate thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , m and n are as defined in the specification. The compounds are antagonists, reverse agonists or agonists of G-protein coupled receptors, such as dopamine D4 and 5HT1a. The inventions also relates to pharmaceutical compositions comprising the compounds and methods involving the compounds and compositions. The compounds and compositions of the invention may in particular be used in the treatment of diseases and disorders, such as neurological and neurodegenerative diseases; or as lead compounds for the design and selection of further therapeutic compounds.

  该发明涉及按照式(I)的吗啡啉衍生物或其立体异构体或药用可接受的盐或溶剂，其中R1、R2、R3、R4、R5、R6、R7、R8、R9、m和n如规范中定义。这些化合物是G蛋白偶联受体的拮抗剂、反向激动剂或激动剂，例如多巴胺D4和5HT1a。该发明还涉及包括这些化合物的药物组合物和涉及这些化合物和组合物的方法。该发明的化合物和组合物特别可用于治疗疾病和障碍，如神经系统和神经退行性疾病；或作为设计和选择进一步治疗化合物的引导化合物。
• PHOTOELECTRIC CONVERSION ELEMENT, DYE-SENSITIZED SOLAR CELL, METAL COMPLEX DYE, DYE SOLUTION, DYE-ADSORBED ELECTRODE, AND METHOD FOR PRODUCING DYE-SENSITIZED SOLAR CELL
  申请人：FUJIFILM Corporation

  公开号：US20150248969A1

  公开（公告）日：2015-09-03

  A photoelectric conversion element, having a photoconductor layercontaining semiconductor fine particles carrying a metal complex dye of Formula (I); a metal complex dye, a dye solution, a dye-adsorbed electrode, a dye-sensitized solar cell, and a method for producing the solar cell: M ( LA )( LD )( LX ) mX ·( CI ) mY Formula (I) M represents a metal ion, LA represents a ligand of Formula (AL), LD represents a bidentate or tridentate ligand, at least one of coordinating atoms being an anion; LX represents a monodentate ligand; CI represents a counter ion; mX is 0 or 1; mY is 0 to 3; Rings A to C represent a heterocycle; Z 1 and Z 2 represent a carbon or nitrogen atom; Anc1 to Anc3 represent an acidic group; X 1 to X 3 represent a single bond or linking group; R 1 to R 3 represent a substituent; l1, l3, l2, m1, m3, m2, n1, n2, and n3 each are an integer.

  一种光电转换元件，具有包含携带公式（I）金属络合染料的半导体细粒子的光电导层；一种金属络合染料，染料溶液，染料吸附电极，染料敏化太阳能电池，以及生产太阳能电池的方法：M（LA）（LD）（LX）mX·（CI）mY公式（I）中，M代表金属离子，LA代表公式（AL）的配体，LD代表双齿或三齿配体，至少一个配位原子是阴离子；LX代表单齿配体；CI代表计数离子；mX为0或1；mY为0到3；环A到C代表杂环；Z1和Z2代表碳或氮原子；Anc1到Anc3代表酸性基团；X1到X3代表单键或连接基团；R1到R3代表取代基；l1、l3、l2、m1、m3、m2、n1、n2和n3各自为整数。
• Organic Electroluminescent Materials and Devices
  申请人：Universal Display Corporation

  公开号：US20170237018A1

  公开（公告）日：2017-08-17

  This invention relates to the development of heterocyclic materials for use as blue phosphorescent materials in OLED devices. The materials are based on a pair of 5 -membered aromatic or psuedoaromatic rings bonded to one another and complexed to a transition metal. The materials were determined computationally to have appropriate triplet energies for use as blue emitters and to possess sufficient chemical stability for use in devices.

  本发明涉及开发杂环材料，用作OLED设备中的蓝色荧光材料。该材料基于两个相互连接的5元芳香或伪芳香环，并与过渡金属配合。计算确定该材料具有适当的三重能级以用作蓝色发射体，并具有足够的化学稳定性以用于设备。