2-(5-bromo-2-dimethylaminophenyl)ethanol | 1399672-04-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(5-bromo-2-dimethylaminophenyl)ethanol
• 英文别名: 2-[5-Bromo-2-(dimethylamino)phenyl]ethanol
• CAS: 1399672-04-8
• 化学式: C₁₀H₁₄BrNO
• 分子量: 244.131
• InChiKey: WMWXCHZZZCORDO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(5-bromo-2-dimethylaminophenyl)ethanol 在 正丁基锂 、 高氯酸 、 氯磷酸二乙酯 作用下， 以 四氢呋喃 、 甲醇 、 乙腈 为溶剂， 反应 0.58h， 生成 [4-[[4-(Dimethylamino)phenyl]-(1,1-dimethyl-2,3-dihydroindol-1-ium-5-yl)methylidene]cyclohexa-2,5-dien-1-ylidene]-dimethylazanium
  参考文献：
  名称：

  Nerve agent simulant detection by using chromogenic triaryl methane cation probes

  摘要：

  Two triaryl methane cations have been used as probes for calorimetric detection of nerve agent simulants. Buffered mixed aqueous solutions of 1 and 2 showed bathochromic shifts in the presence of DCNP (diethylcyanophosphonate) and DCP (diethylchlorophosphate). The colour modulation can be observed to the naked eye. Appropriate mechanisms for the recognition event are proposed. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.07.091
• 作为产物：
  描述：

  在 N-溴代丁二酰亚胺(NBS) 、 ammonium acetate 、 sodium cyanoborohydride 作用下， 以 乙腈 为溶剂， 反应 3.0h， 生成 2-(5-bromo-2-dimethylaminophenyl)ethanol
  参考文献：
  名称：

  异色满和四氢异喹啉的选择性开环胺化

  摘要：

  通过采用分子编辑策略，开发了异色满和四氢异喹啉的新型选择性开环胺化。这种化学提供了一种从容易获得的起始材料中获取各种有价值的化合物的实用方法。

  DOI：

  10.1002/anie.202401318

文献信息

• Functionalized Gold Nanoparticles as an Approach to the Direct Colorimetric Detection of DCNP Nerve Agent Simulant
  作者：Almudena Martí、Ana M. Costero、Pablo Gaviña、Salvador Gil、Margarita Parra、Mauro Brotons-Gisbert、Juan Francisco Sánchez-Royo

  DOI：10.1002/ejoc.201300339

  日期：2013.8

  New functionalized gold nanoparticles have been synthesized and their ability to act as colorimetric molecular probes for the naked-eye detection of nerve agent simulant DCNP has been studied. The detection process is based on the com

  已经合成了新的功能化金纳米粒子，并研究了它们作为比色分子探针用于神经毒剂模拟 DCNP 的肉眼检测的能力。检测过程基于com
• Highly Selective Detection of Nerve‐Agent Simulants with BODIPY Dyes
  作者：Andrea Barba‐Bon、Ana M. Costero、Salvador Gil、Anthony Harriman、Félix Sancenón

  DOI：10.1002/chem.201304475

  日期：2014.5.19

  Two chromo‐fluorogenic probes, each based on the boron dipyrromethene core, have been developed for the detection of nerve‐agent mimics. These chemosensors display both a color change and a significant enhancement of fluorescence in the presence of diethylcyanophosphonate (DCNP) and diisopropylfluorophosphate (DFP). No interference from other organophosphorus compounds or acids has been observed. Two

  已经开发了两种基于铝二吡咯甲烷核心的发色荧光探针，用于检测神经药模拟物。这些化学传感器在氰基膦酸二乙酯（DCNP）和氟代磷酸二异丙酯（DFP）的存在下既显示颜色变化又显示荧光的显着增强。没有观察到其他有机磷化合物或酸的干扰。已经开发并测试了两个便携式化学传感器套件，以证明其在实时监控中的实际应用。
• Ratiometric double channel borondipyrromethene based chemodosimeter for the selective detection of nerve agent mimics
  作者：R. Gotor、A.M. Costero、P. Gaviña、Salvador Gil

  DOI：10.1016/j.dyepig.2014.04.011

  日期：2014.9

  A new chromo-fluorogenic probe based on the borondipyrromethene dye has been synthesized. The dye has been attached to a sensing unit for the diethylcyanophosphonate and di-isopropylfluorophosphate detection. The new probe has been fully characterized, and its optical properties in front of these simulants have been evaluated. No interference from other organo-phosphorous or other common contaminants compounds has been observed in the detection conditions. A portable kit has been developed and tested to demonstrate its practical application in real-time monitoring not only in solution but also in gas phase. (C) 2014 Elsevier Ltd. All rights reserved.