(2-hydroxydibenzofuran-3-yl)methyl ketone | 658698-64-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: (2-hydroxydibenzofuran-3-yl)methyl ketone
• 英文别名: 2-Hydroxy-3-acetyldibenzofuran；1-(2-hydroxydibenzofuran-3-yl)ethanone
• CAS: 658698-64-7
• 化学式: C₁₄H₁₀O₃
• 分子量: 226.232
• InChiKey: BXFJCGGJPBMBFT-UHFFFAOYSA-N

物化性质

• 熔点：
  168-169 °C
• 沸点：
  227 °C(Press: 7 Torr)
• 密度：
  1.327±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  50.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2-hydroxydibenzofuran-3-yl)methyl ketone 在 sodium hydroxide 、 alkaline aqueous potassium hypoiodite solution 、 丙酮 作用下， 生成 2-methoxydibenzofuran-3-carboxylic acid
  参考文献：
  名称：

  Some 1,2-, 2,3- and 3,4-Disubstituted Dibenzofurans

  摘要：

  DOI：

  10.1021/ja01651a051
• 作为产物：
  描述：

  2-羟基二苯并呋喃 在 三氯化铝 、 硫酸 、 1,1,2,2-四氯乙烷 作用下， 生成 (2-hydroxydibenzofuran-3-yl)methyl ketone
  参考文献：
  名称：

  Some 1,2-, 2,3- and 3,4-Disubstituted Dibenzofurans

  摘要：

  DOI：

  10.1021/ja01651a051

文献信息

• Synthesis of Polysubstituted 2‐Naphthols by Palladium‐Catalyzed Intramolecular Arylation/Aromatization Cascade
  作者：Jinhui Cai、Zhen‐Kai Wang、Yun‐Hao Zhang、Fei Yao、Xu‐Dong Hu、Wen‐Bo Liu

  DOI：10.1002/adsc.201901573

  日期：2020.3.17

  A palladium‐catalyzed intramolecular α‐arylation and defluorinative aromatization strategy for the synthesis of polysubstituted 2‐naphthols is reported. With ortho‐bromobenzyl‐substituted α‐fluoroketones as the substrates and palladium acetate/triphenylphosphine as the catalyst, this method features good functional group tolerance, readily available catalyst and starting materials, and high yields

  报道了钯催化的分子内α-芳基化和脱氟芳构化策略，用于合成多取代的2-萘酚。该方法以邻溴苄基取代的α-氟酮为底物，并以乙酸钯/三苯膦为催化剂，具有良好的官能团耐受性，易于获得的催化剂和起始原料以及高收率的特点。该策略的应用通过合成有用的结构单元（例如，石脑油[2,3- b ]呋喃，萘酚AS-D和配体/催化剂）得到证明。
• Psoralen analogues: synthesis, inhibitory activity of growth of human tumor cell lines and computational studies
  作者：A.M.A.G. Oliveira、M. Manuela M. Raposo、A.M.F. Oliveira-Campos、A.E.H. Machado、Prapawadee Puapairoj、Madalena Pedro、Maria São José Nascimento、César Portela、Carlos Afonso、Madalena Pinto

  DOI：10.1016/j.ejmech.2005.10.016

  日期：2006.3

  Eight psoralens have been evaluated for their ability to inhibit the in vitro growth of three human tumor cell lines representing different tumor types, MCF-7 (breast cancer), NCI-H460 (non-small cell lung cancer) and SF-268 (CNS cancer). The synthesis of four new psoralens (benzofurocoumarins) is presented as well as the results of the ab initio calculations to find the parameters that relate the

  已评估了八种补骨脂素抑制三种代表不同肿瘤类型的人类肿瘤细胞系MCF-7（乳腺癌），NCI-H460（非小细胞肺癌）和SF-268（CNS）的体外生长能力癌症）。介绍了四种新补骨脂素（苯并呋喃香豆素）的合成以及从头算的结果，以找到与结构与抗肿瘤活性相关的参数。这项工作提供了补充信息，可以允许开发具有这种类型的生物活性的新补骨脂素类似物。
• Culture wars in the classroom: Prospective teachers question science
  作者：Karen Sullenger、Steve Turner、Hart Caplan、Joe Crummey、Rick Cuming、Cynthia Charron、Beth Corey

  DOI：10.1002/1098-2736(200011)37:9<895::aid-tea3>3.0.co;2-3

  日期：2000.11

  Does studying about the nature(s) of science contribute to a prospective teachers' effectiveness as a science teacher? This research grew out of a course created by a science educator and historian of science who believed prospective teachers needed more complex understandings of the cultural wars surrounding science. The research team consisted of five prospective teachers who participated in the course as well as the two instructors. This paper describes the experience of participating in the course from both perspectives. We argue that studying the cultural wars over science contributes to prospective teachers' professional growth as much because the course elicits tacit beliefs about school science as it introduces more complex understandings of science. We found that prospective teachers' tacit beliefs about school science were their greatest barrier to developing more complex understandings about the nature(s) of science. We contend that willingness to grapple with complexity and developing a professional identity by locating oneself in the conversations about the nature(s) of science are better criteria for determining the professional growth of prospective teachers than knowledge measures. Finally, we argue that prospective teachers should be viewed as professionals who are responsible for finding their own voice, making their own decisions, and considering the consequences of their beliefs on their practice. This study raises questions critical to teacher education programs for prospective teachers and teacher-educators alike. (C) 2000 John Wiley & Sons, Inc.
• Fries rearrangement of dibenzofuran-2-yl ethanoate under photochemical and Lewis-acid-catalysed conditions
  作者：Ana M.A.G Oliveira、Ana M.F Oliveira-Campos、M.Manuela M Raposo、John Griffiths、Antonio E.H Machado

  DOI：10.1016/j.tet.2004.05.060

  日期：2004.7

  The Fries rearrangement of dibenzofuran-2-yl ethanoate as a route to o-hydroxyacetyidibenzofurans has been investigated, both under thermal Lewis-acid catalysed and non-catalysed photochemical conditions. The reactions were examined theoretically at semi-empirical (PM3 and ZINDO/S) and density functional theory (DFT) levels. The correct selection of reaction conditions provides viable preparative routes to ortho-acylated hydroxydibenzofurans. (C) 2004 Elsevier Ltd. All rights reserved.