p-cyclohexylaminophenol | 10014-69-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: p-cyclohexylaminophenol
• 英文别名: 4-(cyclohexylamino)phenol
• CAS: 10014-69-4
• 化学式: C₁₂H₁₇NO
• 分子量: 191.273
• InChiKey: ZWNKVPHOSQGNRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  环己酮 、 对氨基苯酚 在 glucose dehydrogenase 、 葡萄糖 、 nicotinamide adenine dinucleotide phosphate 作用下， 以 aq. phosphate buffer 为溶剂， 反应 4.0h， 生成 p-cyclohexylaminophenol
  参考文献：
  名称：

  通过扩展亚胺还原酶工具箱进行高效的生物催化还原胺化反应

  摘要：

  手性仲胺和叔胺在制药，精细和特种化学品中无处不在，但它们的合成通常面临重大的可持续性和选择性挑战。生物催化替代品，例如酶催化的还原胺化，相对于传统化学方法具有许多优势，但尚未证明其工业适用性。在本文中，我们报道了表达亚胺还原酶的细胞裂解物对多种胺和羰基化合物的化学计量比为1：1的操作。介绍了具有小分子覆盖范围和直接工业适用性的生物催化剂的集合。

  DOI：

  10.1002/cctc.201701379

文献信息

• [EN] SULFONATED NITROPHENOLS AS POLYMERIZATION INHIBITORS<br/>[FR] NITROPHÉNOLS SULFONÉS EN TANT QU'INHIBITEURS DE LA POLYMÉRISATION
  申请人：CHEMTURA CORP

  公开号：WO2006036426A1

  公开（公告）日：2006-04-06

  Disclosed herein is a method for inhibiting and retarding the premature polymerization and the polymer growth of ethylenically unsaturated monomers comprising adding to said monomers an effective amount of at least one inhibitor that is a sulfonated nitrophenol of the formula: (I) wherein: R1, R2, and R3 are independently selected from the group consisting of hydrogen, alkyl, NO2, and S03H, provided that at least one of R,, R2, and R3 is NO2 and at least one of R1, R2, and R3 is SO3H. In a preferred embodiment, at least one additional inhibitor selected from the group consisting of nitroxyl compounds, nitrosoanilines, nitrophenols, amines, and mixtures thereof is also added.

  本文揭示了一种抑制和延缓乙烯基不饱和单体的聚合物的过早聚合和聚合物生长的方法，包括向所述单体中添加至少一种抑制剂，其为公式（I）的磺化硝基苯酚的有效量：其中：R1、R2和R3是独立选择自氢、烷基、NO2和S03H的群组，前提是R1、R2和R3中至少有一个是NO2，且R1、R2和R3中至少有一个是SO3H。在优选实施例中，还添加了至少一种来自亚硝基化合物、亚硝基苯胺、硝基苯酚、胺和它们的混合物的附加抑制剂。
• Two Component Recyclable Heterogeneous Catalyst, Process for Preparation Thereof and its Use for Preparation of Amines
  申请人：Likhar Pravin R.

  公开号：US20110313158A1

  公开（公告）日：2011-12-22

  The invention describes the development of highly efficient, recyclable two component system, CuAl-hydrotalcite/rac 1,1′-Binaphthalene-2,2′-diol catalytic system for the N-alkylation of electron deficient aryl chlorides in presence of potassium carbonate as a base at room temperature in 3-6 h, wherein the process is provided for the preparation of various secondary amines via C—N coupling reaction of aliphatic amines(aliphatic open chain, acyclic, benzyl amines and heterocyclic amines) with various aryl chlorides.

  该发明描述了开发高效、可回收的两组分体系，CuAl-水滑石/rac 1,1′-联萘-2,2′-二酚催化系统，用于在室温下在3-6小时内以碳酸钾为碱催化芳基氯化物的N-烷基化反应，其中该过程提供了通过脂肪胺（脂肪开链、无环、苄胺和杂环胺）与各种芳基氯化物进行C—N偶联反应制备各种二级胺的方法。
• [EN] SULFONATED PHENOLS WITH NITROPHENOLS AS POLYMERIZATION INHIBITORS<br/>[FR] PHENOLS SULFONES AVEC NITROPHENOLS COMME INHIBITEURS DE POLYMERISATION
  申请人：CHEMTURA CORP

  公开号：WO2006036274A1

  公开（公告）日：2006-04-06

  Disclosed herein is a method for inhibiting the premature polymerization and the polymer growth of ethylenically unsaturated monomers comprising adding to said monomers an effective amount of a combination of (A) at least one inhibitor that is a sulfonated phenol of the formula (I): wherein (1) R2 is selected from the group consisting of hydrogen and hydrocarbyl; and (2) R1 and R3 are independently selected from the group consisting of hydrogen and SO3H, provided that at least one of R1 and R3 is SO3H; (B) at least one inhibitor that is a nitrophenol; and, optionally, (C) an inhibitor selected from the group consisting of nitroxyl compounds and nitrosoanilines; and (D) an amine.

  本文公开了一种抑制乙烯基不饱和单体的过早聚合和聚合生长的方法，包括向该单体中添加以下组合物的有效量：（A）至少一种为公式（I）的磺化酚抑制剂，其中（1）R2选自氢和烃基组成的群体；（2）R1和R3独立地选自氢和SO3H组成的群体，但其中至少一个为SO3H；（B）至少一种为硝基酚的抑制剂；以及可选地，（C）从硝基氧化物化合物和硝基苯胺组成的群体中选择的抑制剂；和（D）胺。
• Improved method for producing cycloalkyl aminophenol derivatives
  申请人：KANZAKI PAPER MANUFACTURING COMPANY LIMITED

  公开号：EP0181505A1

  公开（公告）日：1986-05-21

  Cycloalkyl aminophenol derivatives are produced by reacting o-, m- or p-aminophenol with a cycloalkanone having 5 to 12 carbon atoms in the presence of a reducing agent and preferably with the addition of an acid.

  环烷基氨基苯酚衍生物是由邻氨基苯酚、间氨基苯酚或对氨基苯酚与具有 5 至 12 个碳原子的环烷基酮在还原剂的存在下，最好是在加入酸的情况下反应生成的。
• Process for preparing N-alkyl-substituted aminophenols
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0411817A2

  公开（公告）日：1991-02-06

  A process for preparing an N-alkyl-substituted amino­phenol comprises continuously feeding an aldehyde or a ketone to a reaction system containing an organic solvent, e.g., methanol or ethanol, a catalyst for reduction (e.g., Pt or Pd), hydrogen, and an aminophenol to conduct a reductive alkylation reaction, wherein said reductive alkylation react­ion is carried our while continuously adding an organic carboxylic acid (e.g. a mono or di-carboxylic or hydroxy­carboxylic acid of up to 8 carbon atoms), in amount of 0.05 to 5 wt % of the aminophenol, diluted with said solvent. The aldehyde or ketone can first be added to the system apart from the acid, which is added continuously when hydrogen absorption has begun. The process attains a high yield even when the catalyst is repeatedly reused, and does not cause corrosion of equipment.

  一种制备 N-烷基取代氨基苯酚的工艺包括：向含有有机溶剂（如甲醇或乙醇）、还原催化剂（如铂或钯）、氢和氨基苯酚的反应体系中连续加入醛或酮，以进行还原烷基化反应、其中，在进行还原烷基化反应的同时，不断加入用所述溶剂稀释的有机羧酸（例如，碳原子数不超过 8 的单羧酸或二羧酸或羟基羧酸），其用量为氨基苯酚的 0.05 至 5 wt %。醛或酮可以先与酸分开加入体系中，当开始吸氢时再继续加入。 即使催化剂重复使用，该工艺也能达到很高的产量，而且不会对设备造成腐蚀。