6-bromo-N-{4-[1-(4-pyridyl)piperidin-4-ylmethoxy]-phenyl}-2-naphthalenesulphonamide | 194853-12-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 6-bromo-N-{4-[1-(4-pyridyl)piperidin-4-ylmethoxy]-phenyl}-2-naphthalenesulphonamide
• 英文别名: 6-bromo-N-{4-[1-(pyridin-4-yl)piperidin-4-ylmethoxy]-phenyl}-2-naphthalenesulphonamide；6-bromo-N-[4-[(1-pyridin-4-ylpiperidin-4-yl)methoxy]phenyl]naphthalene-2-sulfonamide
• CAS: 194853-12-8
• 化学式: C₂₇H₂₆BrN₃O₃S
• 分子量: 552.492
• InChiKey: IDMWPNKGXNGLJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  79.9
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Aminoheterocyclic derivatives as antithrombotic or anticoagulant agents
  申请人：ZENECA LIMITED

  公开号：US20030207882A1

  公开（公告）日：2003-11-06

  Compounds of formula (I), wherein G 1 is CH or N; G 2 is CH or N; R 1 is a variety of optional substituents, L 1 is (1-4C)alkylene; T 1 is CH or N; R 2 and R 3 are independently hydrogen or (1-4C)alkyl or are joined to form a ring; X 1 and X 2 represent various linking groups; Ar is phenylene or certain heteroaryl rings and Q represents a variety of aromatic or heterocyclic rings systems, and pharmaceutically acceptable salts thereof are described as useful antithrombotic and anticoagulant agents, and are selective Factor Xa inhibitors. Processes for their preparation and pharmaceutical compositions containing them are also described. 1

  式（I）的化合物，其中G1为CH或N；G2为CH或N；R1为各种可选取代基，L1为（1-4C）烷基；T1为CH或N；R2和R3独立地为氢或（1-4C）烷基或连接成环；X1和X2代表各种连接基团；Ar为苯基或特定杂环芳基，Q代表各种芳香或杂环芳基系统，及其药学上可接受的盐被描述为有用的抗血栓和抗凝血剂，并且是选择性的凝血因子Xa抑制剂。还描述了其制备方法和含有它们的药物组合物。
• AMINOHETEROCYCLIC DERIVATIVES AS ANTITHROMBOTIC OR ANTICOAGULANT AGENTS
  申请人：AstraZeneca AB

  公开号：EP0880502B1

  公开（公告）日：2004-09-01