3-(N-benzyl-N-methylaminomethyl)-4,7-dihydro-5-isobutyryl-7-(2,6-difluorobenzyl)-2-(4-cyclopropanecarbonylaminophenyl)-4-oxothieno[2,3-b]pyridine Hydrochloride | 253433-72-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡啶类
• 英文名称: 3-(N-benzyl-N-methylaminomethyl)-4,7-dihydro-5-isobutyryl-7-(2,6-difluorobenzyl)-2-(4-cyclopropanecarbonylaminophenyl)-4-oxothieno[2,3-b]pyridine Hydrochloride
• 英文别名: N-[4-[3-[[benzyl(methyl)amino]methyl]-7-[(2,6-difluorophenyl)methyl]-5-(2-methylpropanoyl)-4-oxothieno[2,3-b]pyridin-2-yl]phenyl]cyclopropanecarboxamide;hydrochloride
• CAS: 253433-72-6
• 化学式: C₃₇H₃₅F₂N₃O₃S*ClH
• 分子量: 676.227
• InChiKey: DZQDTKORWADGCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.3
• 重原子数：
  47
• 可旋转键数：
  11
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  98
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Thienopyridine compounds, their production and use
  申请人：——

  公开号：US20010001104A1

  公开（公告）日：2001-05-10

  The compound of the present invention possesses excellent gonadotropin-releasing hormone antagonizing activity, and is useful for preventing or treating sex hormone-dependent diseases, e.g., sex hormone-dependent cancers (e.g., prostatic cancer, uterine cancer, breast cancer, pituitary tumor), prostatic hypertrophy, hysteromyoma, endometriosis, precocious puberty, amenorrhea syndrome, multilocular ovary syndrome, pimples etc, or as a pregnancy regulator (e.g., contraceptive), infertility remedy or menstruation regulator.

  本发明的化合物具有出色的促性腺激素释放激素拮抗活性，并可用于预防或治疗性激素依赖性疾病，例如性激素依赖性癌症（例如前列腺癌、子宫癌、乳腺癌、垂体肿瘤）、前列腺肥大、子宫肌瘤、子宫内膜异位症、性早熟、闭经综合征、多囊卵巢综合征、痤疮等，或作为妊娠调节剂（例如避孕药）、不孕症疗法或月经调节剂。
• Preventives/remedies for alzheimer's disease
  申请人：——

  公开号：US20030134863A1

  公开（公告）日：2003-07-17

  The present invention provides an agent for the prophylaxis or treatment of Alzheimer's disease. The agent for the prophylaxis or treatment of Alzheimer's disease of the present invention containing a compound having a GnRH antagonistic action shows low toxicity and has a superior preventive and therapeutic effect on Alzheimer's disease.

  本发明提供了一种用于预防或治疗阿尔茨海默病的药剂。本发明的用于预防或治疗阿尔茨海默病的药剂含有具有GnRH拮抗作用的化合物，显示出低毒性，并对阿尔茨海默病具有卓越的预防和治疗效果。
• PREVENTIVES/REMEDIES FOR ALZHEIMER'S DISEASE
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1393747A1

  公开（公告）日：2004-03-03

  The present invention provides an agent for the prophylaxis or treatment of Alzheimer's disease. The agent for the prophylaxis or treatment of Alzheimer's disease of the present invention containing a compound having a GnRH antagonistic action shows low toxicity and has a superior preventive and therapeutic effect on Alzheimer's disease.

  本发明提供了一种预防或治疗阿尔茨海默病的制剂。本发明的预防或治疗阿尔茨海默病的制剂含有一种具有 GnRH 拮抗作用的化合物，毒性低，对阿尔茨海默病有很好的预防和治疗效果。
• US6262267B1
  申请人：——

  公开号：US6262267B1

  公开（公告）日：2001-07-17
• US6297255B1
  申请人：——

  公开号：US6297255B1

  公开（公告）日：2001-10-02