1-Hydroxypromazin | 130349-17-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 1-Hydroxypromazin
• 英文别名: 10-(3-dimethylamino-propyl)-10H-phenothiazin-1-ol；10-[3-(Dimethylamino)propyl]-10H-phenothiazin-1-OL；10-[3-(dimethylamino)propyl]phenothiazin-1-ol
• CAS: 130349-17-6
• 化学式: C₁₇H₂₀N₂OS
• 分子量: 300.425
• InChiKey: GZODTCZGJCLAKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  52
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• DELIVERY OF ANTIPSYCHOTICS THROUGH AN INHALATION ROUTE
  申请人：Alexza Molecular Delivery Corporation

  公开号：EP1389098A1

  公开（公告）日：2004-02-18
• [EN] DELIVERY OF ANTIPSYCHOTICS THROUGH AN INHALATION ROUTE<br/>[FR] ADMINISTRATION D'ANTIPSYCHOTIQUES PAR INHALATION
  申请人：ALEXZA MOLECULAR DELIVERY CORP

  公开号：WO2002094236A1

  公开（公告）日：2002-11-28

  The present invention relates to the delivery of antipsychotics through an inhalation route. Specifically, it relates to aerosols containing antipsychotics that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of an antipsychotic. In a method aspect of the present invention, an antipsychotic is delivered to a mammal through an inhalation route. The method comprises: a) Heating a composition, wherein the composition comprises at least 5 percent by weight of an antipsychotic, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering an antipsychotic through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of an antipsychotic; and, b) a device that forms an antipsychotic containing aerosol from the composition, for inhalation by the mammal.