6-methyl-2-(4-methyl-1-piperidinyl)-N-[2-(1H-pyrazol-1-ylacetyl)-2,3-dihydro-1H-isoindol-5-yl]nicotinamide | 689160-67-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 6-methyl-2-(4-methyl-1-piperidinyl)-N-[2-(1H-pyrazol-1-ylacetyl)-2,3-dihydro-1H-isoindol-5-yl]nicotinamide
• 英文别名: 6-methyl-2-(4-methylpiperidin-1-yl)-N-[2-(2-pyrazol-1-ylacetyl)-1,3-dihydroisoindol-5-yl]pyridine-3-carboxamide
• CAS: 689160-67-6
• 化学式: C₂₆H₃₀N₆O₂
• 分子量: 458.563
• InChiKey: LAZVMJACNUCKDL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  83.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-(1H-pyrazol-1-ylacetyl)-5-isoindolinamine 、 6-methyl-2-(4-methyl-1-piperidinyl)nicotinic acid 在 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 20.0h， 生成 6-methyl-2-(4-methyl-1-piperidinyl)-N-[2-(1H-pyrazol-1-ylacetyl)-2,3-dihydro-1H-isoindol-5-yl]nicotinamide
  参考文献：
  名称：

  [EN] AMIDE COMPOUNDS FOR THE TREATMENT OF HYPERLIPIDEMIA
  [FR] COMPOSES AMIDE

  摘要：

  公开号：

  WO2004039795A3

文献信息

• Amide compounds
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：US20040133008A1

  公开（公告）日：2004-07-08

  A compound of the formula (I) 1 wherein R 1 is hydrogen, lower alkyl, lower alkenyl, halo(lower)alkyl, cyclo(lower)alkyl, lower alkoxy, lower alkylthio, acyl, optionally substituted aryl or NR 3 R 4 ; R 2 is hydrogen; or aryl or heteroaryl, each of which may be substituted; X is direct bond or bivalent residue derived from piperazine; Y is -(A 1 ) n -(A 2 ) m -, wherein n and m are independently 0 or 1); 2 is bivalent residue derived from arene or heteroarene; and 3 is bivalent residue derived from arene or heteroarene, or a salt thereof. The compound of the present invention and a salt thereof inhibit apolipoprotein B (Apo B) secretion and are useful as a medicament for prophylactic and treatment of diseases or conditions resulting from elevated circulating levels of Apo B.

  化合物的式子为（I）1，其中R1为氢、低级烷基、低级烯基、卤素（低）烷基、环（低）烷基、低级烷氧基、低级烷硫基、酰基、可选取代的芳基或NR3R4；R2为氢；或芳基或杂环芳基，每个可以被取代；X为直接键或由哌嗪衍生的二价残基；Y为-(A1)n-(A2)m-，其中n和m独立地为0或1）；2为由芳烃或杂芳烃衍生的二价残基；3为由芳烃或杂芳烃衍生的二价残基，或其盐。本发明的化合物及其盐抑制载脂蛋白B（Apo B）的分泌，并可用作预防和治疗由高循环Apo B水平引起的疾病或状况的药物。
• [EN] AMIDE COMPOUNDS<br/>[FR] COMPOSES AMIDE
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2004039795A2

  公开（公告）日：2004-05-13

  A compound of the formula (I) Wherein R1 is hydrogen, lower alkyl, lower alkenyl, halo(lower)alkyl, cyclo(lower)alkyl, lower alkoxy, lower alkylthio, acyl, optionally substituted aryl or NR3R4; R2 is hydrogen; or aryl or heteroaryl, each of which may be substituted; X is direct bond or bivalent residue derived from piperazine; Y is -(A1)n-(A2)m-, wherein n and m are independently 0 or 1) ; (II) is bivalent residue derived from arene or heteroarene; and (III) is bivalent residue derived from arene or heteroarene, or a salt thereof. The compound of the present invention and a salt thereof inhibit apolipoprotein B (Apo B) secretion and are useful as a medicament for prophylactic and treatment of diseases or conditions resulting from elevated circulating levels of Apo B.
• [EN] AMIDE COMPOUNDS FOR THE TREATMENT OF HYPERLIPIDEMIA<br/>[FR] COMPOSES AMIDE
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2004039795A3

  公开（公告）日：2005-03-24