1-methoxycyclopropanecarboximidamide hydrochloride | 426828-35-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-methoxycyclopropanecarboximidamide hydrochloride
• 英文别名: 1-Methoxycyclopropane-1-carboximidamide;hydrochloride
• CAS: 426828-35-5
• 化学式: C₅H₁₀N₂O*ClH
• 分子量: 150.608
• InChiKey: DYZPMBIBDLSYOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.52
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  59.1
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  乙基1-甲氧基环丙烷羧酸酯 在 ammonium chloride 、 三甲基铝 作用下， 以 正己烷 、 甲苯 为溶剂， 以87%的产率得到1-methoxycyclopropanecarboximidamide hydrochloride
  参考文献：
  名称：

  A novel approach to amidines from esters

  摘要：

  A mild and efficient method for the direct conversion of aromatic, benzylic and aliphatic esters to amidines in the form of their hydrochlorides-has been developed. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)02162-1

文献信息

• [EN] 5-ETHYL-IMIDAZO (5,1-F) (1,2,4,) TRIAZIN-4 (3H) -ONES AS PHOSPHODIESTERASE INHIBITORS<br/>[FR] 5-ETHYL-IMIDAZO(5,1-F)(1,2,4,)TRIAZIN-4(3H)-ONES COMME INHIBITEURS DE PHOSPHODIESTERASE
  申请人：BAYER AG

  公开号：WO2003093270A1

  公开（公告）日：2003-11-13

  The invention relates to novel 5-ethyl-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.

  这项发明涉及新型的5-乙基咪唑三唑酮，其制备方法以及它们在药物中的应用，特别是用于治疗和/或预防炎症过程和/或免疫性疾病。
• 5-ethyl-imidazo (5,1-F) (1,2,4,) triazin-4 (3h)-ones as phosphodiesterase inhibitors
  申请人：Alonso-Alija Cristina

  公开号：US20050272732A1

  公开（公告）日：2005-12-08

  The invention relates to novel 5-ethyl-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.

  本发明涉及新型5-乙基咪唑三嗪酮的制备方法及其在药物中的应用，尤其是用于治疗和/或预防炎症过程和/或免疫性疾病。
• HETEROCYCLIC COMPOUND
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US20160264536A1

  公开（公告）日：2016-09-15

  The problem of the present invention is to provide a compound having a PDE2A inhibitory action, and useful as a prophylactic or therapeutic drug for schizophrenia, Alzheimer's disease and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

  本发明的问题是提供一种具有PDE2A抑制作用的化合物，可用作预防或治疗精神分裂症、阿尔茨海默病等疾病的药物。本发明涉及一种由式（I）表示的化合物：其中每个符号如在说明书中所述，或其盐。
• 5-ETHYL-IMIDAZO[5,1-F][1,2,4]TRIAZIN-4(3H)-ONES AS PHOSPHODIESTERASE INHIBITORS
  申请人：Bayer Aktiengesellschaft

  公开号：EP1504006A1

  公开（公告）日：2005-02-09
• A novel approach to amidines from esters
  作者：Heike Gielen、Cristina Alonso-Alija、Martin Hendrix、Ulrich Niewöhner、Dagmar Schauss

  DOI：10.1016/s0040-4039(01)02162-1

  日期：2002.1

  A mild and efficient method for the direct conversion of aromatic, benzylic and aliphatic esters to amidines in the form of their hydrochlorides-has been developed. (C) 2002 Elsevier Science Ltd. All rights reserved.