8-methoxy-7H-purin-2-amine | 138949-62-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 8-methoxy-7H-purin-2-amine
• CAS: 138949-62-9
• 化学式: C₆H₇N₅O
• 分子量: 165.15
• InChiKey: WNJDOLZIXKQMDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  89.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• A PROCESS FOR SEQUENCE SATURATION MUTAGENESIS (SESAM)
  申请人：BASF Aktiengesellschaft

  公开号：EP1670914A1

  公开（公告）日：2006-06-21
• [EN] A PROCESS FOR SEQUENCE SATURATION MUTAGENESIS (SESAM)<br/>[FR] MUTAGENESE A SATURATION DE SEQUENCE
  申请人：BASF AG

  公开号：WO2005035757A1

  公开（公告）日：2005-04-21

  A process for the mutagenesis of a double-stranded polynucleotide sequence (master sequence) of n base-pairs having a (+)-strand and a complementary (-)-strand comprising the steps (i) creation of a collection of single-stranded fragments of the (+)-strand of the master sequence wherein all members of the collection have the same 5'-terminus and have a deletion in the 3'-terminus such that the collection represents (+)-strands with a length of n-1, n-2, n-3, ..... nucleotides; (ii) introduction of at least one universal or degenerate nucleotide at the 3'-terminus of the (+) strand produced in step (i); (iii) elongation of the (+)-strand produced in step (ii) to the full length of the master sequence using the (-)-strand or fragments thereof as a template strand for the elongation; (iv) synthesis of a (-)-strand by using the (+)-strand produced in step (iii) as a template strand thereby effecting mutations in the (-)-strand at the positions of the previous universal or degenerate nucleotides compared to the master sequence.