5-Hydroxy-2,2-dimethyl-pentanenitrile | 1468587-64-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 5-Hydroxy-2,2-dimethyl-pentanenitrile
• 英文别名: 5-Hydroxy-2,2-dimethylpentanenitrile
• CAS: 1468587-64-5
• 化学式: C₇H₁₃NO
• 分子量: 127.186
• InChiKey: JFMCFDHFFLIOIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  44
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  异丁腈 、 烯丙醇 在 偶氮二异丁腈 作用下， 以 甲苯 为溶剂， 生成 5-Hydroxy-2,2-dimethyl-pentanenitrile
  参考文献：
  名称：

  Rate constants for the addition of the 2-cyano-2-propyl radical to alkenes in solution

  摘要：

  AbstractAbsolute rate constants for the addition of the 2‐cyano‐2‐propyl radical to 26 alkenes CH2=CXY at 315 K were determined in solution by time‐resolved electron‐spin‐resonance spectroscopy. They vary with the alkene substituents from 30 M−1 s−1 to 7′010 M−1 s−1. For styrene the temperature dependence is given by log k/M−1 s−1 = 7.7 − 26.1/Θ where Θ = 2.303 RT in kJ/mol. An analysis of the substituent effects in terms of polar and enthalpic factors reveals a dominant influence of the overall reaction enthalpy. © 1993 John Wiley & Sons, Inc.

  DOI：

  10.1002/kin.550250405

文献信息

• POLYMERISATION USING CHAIN TRANSFER AGENTS
  申请人：Perrier Sebastian

  公开号：US20090215965A1

  公开（公告）日：2009-08-27

  The invention provides a process for synthesising functionalised chain transfer polymers of Formula (1) or Formula (2) using thiocarbonyl thio compounds as chain transfer agents. Why R1 is a moiety comprising a functional group; Q is obtained from an olefinically unsaturated monomer; R′ is selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, an aromatic saturated or unsaturated carbocyclic or heterocyclic ring, optionally substituted with one or more substituents, amino alkyl, cyanoalkyl, hydroxylalkyl, saturated and unsaturated amido; an organometallic species, a polymer chain and any of the foregoing substituted with one or more CN or OH groups; q=an integer of at least 2; p=an integer of at least 1. Chain transfer agents and polymers produced by the method are also provided.

  该发明提供了一种合成功能化链转移聚合物的方法，使用硫代羰基硫化合物作为链转移剂，其化学式为(1)或(2)。其中，R1是包含功能基团的基团；Q是从烯烃不饱和单体获得的；R′选自包括烷基、取代烷基、烷氧基、取代烷氧基、芳香饱和或不饱和碳环或杂环环，可选地取代一个或多个取代基，氨基烷基、氰基烷基、羟基烷基、饱和和不饱和酰胺的基团；有机金属物种、聚合物链和上述任何一种基团，其中取代有一个或多个CN或OH基团；q至少为2的整数；p至少为1的整数。该方法还提供了链转移剂和由该方法产生的聚合物。
• Polymerisation Using Chain Transfer Agents
  申请人：Perrier Sebastien

  公开号：US20100160574A1

  公开（公告）日：2010-06-24

  The invention provides a process for synthesising functionalised chain transfer polymers of Formula (1) or Formula (2) using thiocarbonyl thio compounds as chain transfer agents. Why R1 is a moiety comprising a functional group; Q is obtained from an olefinically unsaturated monomer; R′ is selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, an aromatic saturated or unsaturated carbocyclic or heterocyclic ring, optionally substituted with one or more substituents, amino alkyl, cyanoalkyl, hydroxylalkyl, saturated and unsaturated amido; an organometallic species, a polymer chain and any of the foregoing substituted with one or more CN or OH groups; q=an integer of at least 2; p=an integer of at least 1. Chain transfer agents and polymers produced by the method are also provided.
• US5990158A
  申请人：——

  公开号：US5990158A

  公开（公告）日：1999-11-23
• [EN] POLYMER DERIVATIVES OF MERTANSINE AND THERAPEUTIC USES THEREOF<br/>[FR] DÉRIVÉS POLYMÈRES DE MERTANSINE ET LEURS UTILISATIONS THÉRAPEUTIQUES
  申请人：[en]IMESCIA

  公开号：WO2022263627A1

  公开（公告）日：2022-12-22

  The present invention relates to polymer derivatives of mertansine (DM1) or of analogues thereof (e.g., DM4), preferably to polyacrylamide derivatives, of formula (A), or a pharmaceutically acceptable salt and/or solvate thereof, wherein m is 0 or 1, L is a linker, M is a hydrophilic polymeric moiety selected from polyacrylamide, polyacrylic acid, poly(N-(2-hydroxypropyl)methacrylamide), poly(oligo(ethylene glycol)methyl ether methacrylate), poly(2-methacryloxyethyl phosphorylcholine), and copolymers thereof, and RA is a terminal group, as defined in the application. The mertansine polymer derivatives of the invention are useful in the treatment of cancers. The invention also relates to a manufacturing process of the mertansine polymer derivatives.