6-(1H-imidazol-1-yl)-2-phenylquinazoline fumarate | 1257259-98-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-(1H-imidazol-1-yl)-2-phenylquinazoline fumarate
• 英文别名: (E)-but-2-enedioic acid;6-imidazol-1-yl-2-phenylquinazoline
• CAS: 1257259-98-5
• 化学式: C₄H₄O₄*C₁₇H₁₂N₄
• 分子量: 388.382
• InChiKey: QXFIIPBQSKGHJH-WLHGVMLRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.19
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  118
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  6-(1H-咪唑-1-基)-2-苯基-喹唑啉 、 富马酸 以 乙醇 为溶剂， 反应 0.25h， 生成 6-(1H-imidazol-1-yl)-2-phenylquinazoline fumarate
  参考文献：
  名称：

  [EN] CRYSTALLINE FORMS OF 6-(1H- IMADAZOL- 1-YL) -2-PHENYLQUINAZOLINE
  [FR] FORMES CRISTALLINES DE LA 6-(1H-IMIDAZOL-1-YL)-2-PHÉNYLQUINAZOLINE ET SELS ASSOCIÉS

  摘要：

  公开号：

  WO2010140139A3

文献信息

• CRYSTALLINE FORMS OF 6-(1H-IMIDAZOL-1-YL)-2-PHENYLQUINAZOLINE
  申请人：Giordani Antonio

  公开号：US20120142713A1

  公开（公告）日：2012-06-07

  The present invention relates to the solid state of 6-(1H-imidazol-1-yl)-2-phenylquinazoline (I) and therefore to novel crystalline forms of the base and of pharmaceutically acceptable salts and solvates thereof, and also to methods for preparing them, to the respective pharmaceutical formulations and to their therapeutic use. Compound (I) may be obtained as the free base in five different crystalline forms, three polymorphic forms and two hydrates. Some pharmaceutically acceptable salts of (I) that have physicochemical characteristics acceptable for pharmaceutical development were obtained, and the respective polymorphic forms and/or hydrates were characterized.

  本发明涉及6-(1H-咪唑-1-基)-2-苯基喹唑啉(I)的固态，因此涉及该碱和其药学可接受的盐和溶剂化合物的新晶体形式，以及制备它们的方法，相应的药物配方和它们的治疗用途。化合物(I)可以作为自由碱体在五种不同的晶体形式中获得，其中包括三种多形形式和两种水合物。获得了一些具有药学可接受的物理化学特性的(I)的药学可接受的盐，并对相应的多形形式和/或水合物进行了表征。
• CRYSTALLINE FORMS OF 6- ( 1H- IMIDAZOL- 1-YL) -2-PHENYLQUINAZOLINE AND SALTS THEREOF
  申请人：Rottapharm S.p.A.

  公开号：EP2438058A2

  公开（公告）日：2012-04-11
• US9174966B2
  申请人：——

  公开号：US9174966B2

  公开（公告）日：2015-11-03
• [EN] CRYSTALLINE FORMS OF 6- ( 1H- IMIDAZOL- 1-YL) -2-PHENYLQUINAZOLINE AND SALTS THEREOF<br/>[FR] FORMES CRISTALLINES DE LA 6-(1H-IMIDAZOL-1-YL)-2-PHÉNYLQUINAZOLINE ET SELS ASSOCIÉS
  申请人：ROTTAPHARM SPA

  公开号：WO2010140139A2

  公开（公告）日：2010-12-09

  The present invention relates to the solid state of 6-(1H-imidazol-1-yl)-2- phenylquinazoline (I) and therefore to novel crystalline forms of the base and of pharmaceutically acceptable salts and solvates thereof, and also to methods for preparing them, to the respective pharmaceutical formulations and to their therapeutic use. Compound (I) may be obtained as the free base in five different crystalline forms, three polymorphic forms and two hydrates. Some pharmaceutically acceptable salts of (I) that have physicochemical characteristics acceptable for pharmaceutical development were obtained, and the respective polymorphic forms and/or hydrates were characterized.