2-[(2S)-2-amino-3-pyridin-4-ylpropyl]isoindole-1,3-dione | 943325-57-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-[(2S)-2-amino-3-pyridin-4-ylpropyl]isoindole-1,3-dione
• CAS: 943325-57-3
• 化学式: C₁₆H₁₅N₃O₂
• 分子量: 281.314
• InChiKey: XPFXAIWPEFNMSN-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  76.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  tert-butyl (S)-(1-(1,3-dioxoisoindolin-2-yl)-3-(pyridin-4-yl)propan-2-yl)carbamate 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 生成 2-[(2S)-2-amino-3-pyridin-4-ylpropyl]isoindole-1,3-dione
  参考文献：
  名称：

  Discovery of 5-pyrrolopyridinyl-2-thiophenecarboxamides as potent AKT kinase inhibitors

  摘要：

  A pyrrolopyridinyl thiophene carboxamide 7 was discovered as a tractable starting point for a lead optimization effort in an AKT kinase inhibition program. SAR studies aided by a co-crystal structure of 7 in AKT2 led to the identification of AKT inhibitors with subnanomolar potency. Representative compounds showed antiproliferative activity as well as inhibition of phosphorylation of the downstream target GSK3 beta. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.02.094

文献信息

• Dihydropyrazole azepine compound serving as Akt inhibitor
  申请人：HARBIN ZHENBAO PHARMACEUTICAL CO., LTD.

  公开号：US10654868B2

  公开（公告）日：2020-05-19

  Provided is a dihydropyrazole azepine compound serving as an Akt inhibitor; specifically disclosed is a compound as represented by formula (I) or a pharmaceutically acceptable salt thereof.

  本发明提供了一种可作为 Akt 抑制剂的二氢吡唑氮杂卓化合物；具体公开了一种由式（I）表示的化合物或其药学上可接受的盐。
• INHIBITORS OF Akt ACTIVITY
  申请人：SmithKline Beecham Corporation

  公开号：EP1968568A2

  公开（公告）日：2008-09-17
• DIHYDROPYRAZOLE AZEPINE COMPOUND SERVING AS AKT INHIBITOR
  申请人：MEDSHINE DISCOVERY INC.

  公开号：US20190233434A1

  公开（公告）日：2019-08-01

  Provided is a dihydropyrazole azepine compound serving as an Akt inhibitor; specifically disclosed is a compound as represented by formula (I) or a pharmaceutically acceptable salt thereof.
• [EN] INHIBITORS OF Akt ACTIVITY<br/>[FR] INHIBITEURS D'ACTIVITE Akt
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2007076423A2

  公开（公告）日：2007-07-05

  [EN] Invented are novel thiophene compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.
  [FR] La présente invention concerne des composés de thiophène atypiques, l'utilisation de tels composés comme inhibiteurs de l'activité de la protéine kinase B et pour le traitement du cancer et de l'arthrite.
• [EN] AMINO-SUBSTITUTED HETEROCYCLES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH<br/>[FR] HÉTÉROCYCLES SUBSTITUÉS PAR AMINO, COMPOSITIONS À BASE DE CEUX-CI ET PROCÉDÉS DE TRAITEMENT À L'AIDE DE CEUX-CI
  申请人：SIGNAL PHARM LLC

  公开号：WO2008036308A2

  公开（公告）日：2008-03-27

  [EN] Provided herein are Heterocyclic Compounds having the following structure: Formula (I) wherein R¹, R², X, Y and Z are as defined herein, compositions comprising an effective amount of a Heterocyclic Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heterocyclic Compound to a patient in need thereof.
  [FR] L'invention concerne des composés hétérocycliques présentant la structure suivante : Formule (I) dans laquelle R¹, R², X, Y et Z sont tels que définis présentement, des compositions comprenant une quantité efficace d'un composé hétérocyclique et des procédés pour traiter ou prévenir un cancer, des conditions inflammatoires, des conditions immunologiques, des conditions métaboliques et des conditions que l'on peut traiter ou prévenir par l'inhibition d'une voie de kinase comprenant l'administration d'une quantité efficace d'un composé hétérocyclique à un patient en ayant besoin.