(2R,3R,4S)-2-(6-Amino-9H-purin-9-yl)oxolane-3,4-diol | 14266-03-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: (2R,3R,4S)-2-(6-Amino-9H-purin-9-yl)oxolane-3,4-diol
• 英文别名: (2R,3R,4S)-2-(6-aminopurin-9-yl)oxolane-3,4-diol
• CAS: 14266-03-6
• 化学式: C₉H₁₁N₅O₃
• 分子量: 237.22
• InChiKey: DTGVOXMKTYPSSO-AFEQZKEHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  119
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• INHIBITORS OF PROTEIN METHYLTRANSFERASE DOT1L AND METHODS OF USE THEREOF
  申请人：Epizyme, Inc.

  公开号：EP2882750A1

  公开（公告）日：2015-06-17
• [EN] DOUBLE STRANDED OLIGONUCLEOTIDE COMPOUNDS COMPRISING POSITIONAL MODIFICATIONS<br/>[FR] COMPOSÉS OLIGONUCLÉOTIDIQUES À DOUBLE BRIN COMPRENANT DES MODIFICATIONS DE POSITION
  申请人：QUARK PHARMACEUTICALS INC

  公开号：WO2012078536A2

  公开（公告）日：2012-06-14

  Disclosed herein are double stranded RNA molecules which have been modified to exhibit one of the following, increased activity, enhanced nuclease stability, reduced off target activity and or reduced immunogenicity, to pharmaceutical compositions comprising such compounds and to methods of use. Further disclosed is a method for the synthesis of threose nucleic acid phosphoramidites and methods of use thereof.
• [EN] INHIBITORS OF PROTEIN METHYLTRANSFERASE DOT1L AND METHODS OF USE THEREOF<br/>[FR] INHIBITEURS DE PROTÉINE MÉTHYLTRANSFÉRASE DE DOT1L ET LEURS PROCÉDÉS D'UTILISATION
  申请人：EPIZYME INC

  公开号：WO2014026198A1

  公开（公告）日：2014-02-13

  The present invention relates to DOT1L inhibitors and methods of identifying, designing, or optimizing them. The present invention also relates to crystals of DOT1L- inhibitor complexes, the crystal structures thereof, and the use of the crystal structures. Also disclosed are pharmaceutical compositions containing these DOT1L inhibitors and methods of treating disorders in which DOT1-mediated protein methylation plays a part, such as cancer and neurological disorders, by administering these compounds and pharmaceutical compositions to subjects in need thereof.