estriol | 651-50-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: estriol
• 英文别名: estra-1,3,5(10)-triene-3,16,17-triol；(8R,9S,13S,14S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol
• CAS: 651-50-3
• 化学式: C₁₈H₂₄O₃
• 分子量: 288.387
• InChiKey: PROQIPRRNZUXQM-BHKMRHFASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  丹酰氯 、 estriol 在 Duolite A-102D 作用下， 以 丙酮 为溶剂， 反应 0.08h， 以48%的产率得到DNS-estriol
  参考文献：
  名称：

  A convenient derivatization with anion exchange resin catalysts for high-performance liquid chromatographic analysis. I. Derivatization of estrogens with dansyl chloride.

  摘要：

  阴离子交换树脂Duolite A-101D、A-102D和A-109被应用于雌激素与丹酯氯（DNS-Cl）的荧光衍生化，以便进行高效液相色谱分析。通过将雌激素与DNS-Cl的混合溶液在丙酮中通过填有Duolite A-102D（OH-形式）的小柱，衍生化过程迅速且高效，产生了相应的DNS-雌激素，产率极高。这种使用树脂柱的程序具有实用价值，并可适用于其他分析样品的衍生化。

  DOI：

  10.1248/cpb.33.5092

文献信息

• Use of estrogens or antiandrogens for reversal of male sexual phenotype in poultry
  申请人：MERCK & CO. INC.

  公开号：EP0514056A2

  公开（公告）日：1992-11-19

  Fertilized poultry embryos are treated with estrogens or antiandrogens or estrogens in combination with antiandrogens during a period of embryonic development when the gonads are bipotential. This treatment causes genetic males to exhibit a female phenotype. When sex reversed male birds are crossed with normal male birds all offspring will be genotypically male.

  受精的家禽胚胎在胚胎发育期间，性腺处于双潜能期，此时使用雌激素或抗雄激素，或雌激素与抗雄激素联合使用。这种处理方法会使遗传雄性表现出雌性表型。当性别逆转的雄性鸟类与正常雄性鸟类杂交时，所有后代的基因型都是雄性。
• Fatty-acid monoesters of estrogens for the treatment of obesity and/or overweight
  申请人：LABORATORIOS S.A.L.V.A.T., S.A.

  公开号：EP0771817A2

  公开（公告）日：1997-05-07

  The estrogen is selected from the group consisting of estrone, diethylstilbestrol, estriol, estradiol and ethinyl estradiol; the fatty acid is selected from the group consisting of oleic, linoleic, linolenic, stearic, palmitic, palmitoleic and arachidonic acids. They mimic the function of estrone monooleate, as a signal that informs the brain of the size of fat tissue mass. Preferred compositions for intravenous injection comprise the monoester incorporated in a lipidic suspension, prepared from lipoproteins or from liposome components such a soy oil and egg phospolipids. When administered to rats with a 15% of total adipose tissue, they produce weight reduction of about 10%, by a new and unexpected mechanism. They are useful for the treatment of obesity and/or overweight in mammals, with the advantages of high efficacy and low toxicity.

  雌激素选自雌酮、己烯雌酚、雌三醇、雌二醇和炔雌醇组成的组；脂肪酸选自油酸、亚油酸、亚麻酸、硬脂酸、棕榈酸、棕榈油酸和花生四烯酸组成的组。它们模仿单油酸雌酮的功能，作为一种信号，告知大脑脂肪组织的大小。用于静脉注射的优选组合物包括掺入脂质悬浮液中的单酯，该悬浮液由脂蛋白或脂质体成分（如大豆油和鸡蛋磷脂）制备而成。当给总脂肪组织含量为 15%的大鼠用药时，它们通过一种意想不到的新机制使体重减轻约 10%。它们具有高效、低毒的优点，可用于治疗哺乳动物的肥胖和/或超重。
• Compositions and methods for delivery of genetic material
  申请人：Wyeth

  公开号：EP1616578A1

  公开（公告）日：2006-01-18

  Methods of introducing genetic material into cells of an individual and compositions and kits for practising the same are disclosed. The methods comprise the steps of contacting cells of an individual with a genetic vaccine facilitator and administering to the cells a nucleic acid molecule that is free of retroviral particles. The nucleic acid molecule comprises a nucleotide sequence that encodes a protein that comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen or antigen associated with a hyperproliferative or autoimmune disease, a protein otherwise missing from the individual due to a missing, non-functional or partially functioning gene, or a protein that produces a therapeutic effect on an individual. Methods of prophylactically and therapeutically immunizing an individual against HIV are disclosed. Pharmaceutical compositions and kits for practising methods of the present invention are disclosed.

  本发明公开了将遗传物质导入人体细胞的方法以及用于实施该方法的组合物和试剂盒。这些方法包括以下步骤：用基因疫苗促进剂接触人体细胞，并给细胞注射不含逆转录病毒颗粒的核酸分子。核酸分子包括一个核苷酸序列，该序列编码一种蛋白质，该蛋白质包括至少一个表位，该表位与病原体抗原或与过度增殖性疾病或自身免疫性疾病相关的抗原的表位相同或基本相似；一种由于基因缺失、无功能或部分功能而在个体中缺失的蛋白质；或一种对个体产生治疗效果的蛋白质。本发明公开了预防性和治疗性免疫艾滋病病毒的方法。公开了用于实施本发明方法的药物组合物和试剂盒。
• Advanced drug development and manufacturing
  申请人：Los Alamos National Security, LLC

  公开号：EP2511844A2

  公开（公告）日：2012-10-17

  There is described an apparatus for measuring protein characteristics comprising an X-ray fluorescence (XRF) spectrometer comprising a source of polychromatic X-rays, an X-ray detector, a protein, a molecule that has been exposed to and at least weakly binds to the protein, a plurality of X-ray fluorescence signal data obtained by irradiating chemical elements in the protein and molecule with the polychromatic X-rays and a security system for maintaining records for the data from the plurality of X-ray fluorescence signal measurements. There is also described an x-ray microscope for measuring a sample.

  描述了一种测量蛋白质特性的仪器，该仪器包括一个 X 射线荧光 (XRF) 光谱仪，其中包括一个多色 X 射线源、一个 X 射线探测器、一个蛋白质、一个已暴露于该蛋白质并至少与该蛋白质弱结合的分子、通过用多色 X 射线照射蛋白质和分子中的化学元素而获得的多个 X 射线荧光信号数据，以及一个用于维护多个 X 射线荧光信号测量数据记录的安全系统。此外，还介绍了一种用于测量样品的 X 射线显微镜。
• Dosage form of an estriol and glatiramer acetate polymer-1 for the treatment of multiple sclerosis
  申请人：The Regents of The University of California

  公开号：EP2698167A2

  公开（公告）日：2014-02-19

  The present invention relates to a dosage form comprising estriol and glatiramer acetate polymer-1 for use in the treatment of multiple sclerosis (MS), as well as to a kit comprising estriol and glatiramer acetate polymer-1.

  本发明涉及一种用于治疗多发性硬化症（MS）的由雌三醇和醋酸格拉替雷聚合体-1组成的剂型，以及由雌三醇和醋酸格拉替雷聚合体-1组成的试剂盒。