3-(3,4-dichlorobenzyl)-4-oxo-N-(2-phenoxyethyl)-4H-pyrido[1,2-a]pyrimidine-7-carboxamide | 1223009-73-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 3-(3,4-dichlorobenzyl)-4-oxo-N-(2-phenoxyethyl)-4H-pyrido[1,2-a]pyrimidine-7-carboxamide
• 英文别名: 3-[(3,4-dichlorophenyl)methyl]-4-oxo-N-(2-phenoxyethyl)pyrido[1,2-a]pyrimidine-7-carboxamide
• CAS: 1223009-73-1
• 化学式: C₂₄H₁₉Cl₂N₃O₃
• 分子量: 468.339
• InChiKey: UFZNCYMCLJJMMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  71
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] PYRIDO- AND PYRIMIDO (1, 2-A) PYRIMIDINE COMPOUNDS USEFUL AS STEAROYL COA DESATURASE INHIBITORS<br/>[FR] COMPOSÉS PYRIDO- ET PYRIMIDO (1, 2-A) PYRIMIDINE UTILES COMME INHIBITEURS DE LA STÉAROYL-COA-DÉSATURASE
  申请人：GILEAD PALO ALTO INC

  公开号：WO2010045371A1

  公开（公告）日：2010-04-22

  The present invention discloses lH-pyrido[l,2-a]pyrimidin-4(9aH)~one derivatives or IH- pyrimido[l,2-a]pyrimidin-4(9aH)~one derivatives for use as inhibitors of stearoyl-CoA desaturase having the structure of Formula I: Formula I. The compounds are useful in treating and/or preventing various human diseases mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cardiovascular disease, cancer, diabetes, obesity, metabolic syndrome and the like.

  本发明公开了用作硬脂酰辅酶A脱饱和酶抑制剂的lH-吡啶并[l,2-a]嘧啶-4(9aH)~酮衍生物或IH-嘧啶并[l,2-a]嘧啶-4(9aH)~酮衍生物，其具有以下结构的结构：公式I。这些化合物可用于治疗和/或预防由硬脂酰辅酶A脱饱和酶（SCD）酶介导的各种人类疾病，特别是与异常脂质水平、心血管疾病、癌症、糖尿病、肥胖、代谢综合征等相关的疾病。
• HETEROCYCLIC COMPOUNDS USEFUL AS STEAROYL CoA DESATURASE INHIBITORS
  申请人：Koltun Dmitry

  公开号：US20100267748A1

  公开（公告）日：2010-10-21

  The present invention discloses 1H-pyrido[1,2-a]pyrimidin-4(9aH)-one derivatives or 1H-pyrimido[1,2-a]pyrimidin-4(9aH)-one derivatives for use as inhibitors of stearoyl-CoA desaturase having the structure of Formula I: The compounds are useful in treating and/or preventing various human diseases mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cardiovascular disease, cancer, diabetes, obesity, metabolic syndrome and the like.

  本发明揭示了用于作为硬脂酰辅酶A去饱和酶抑制剂的1H-吡啶并[1,2-a]嘧啶-4(9aH)-酮衍生物或1H-嘧啶并[1,2-a]嘧啶-4(9aH)-酮衍生物，其具有以下结构式I：该化合物可用于治疗和/或预防由硬脂酰辅酶A去饱和酶（SCD）酶介导的各种人类疾病，特别是与异常脂质水平、心血管疾病、癌症、糖尿病、肥胖症、代谢综合征等有关的疾病。