ergosta-5,7,14,22t-tetraen-3β-ol | 10088-64-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: ergosta-5,7,14,22t-tetraen-3β-ol
• 英文别名: (22E,24S)-24-methylcholesta-5,7,14,22-tetraen-3beta-ol；(3S,9R,10R,13R,17R)-17-[(E,2R,5R)-5,6-dimethylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,9,11,12,16,17-octahydro-1H-cyclopenta[a]phenanthren-3-ol
• CAS: 10088-64-9
• 化学式: C₂₈H₄₂O
• 分子量: 394.641
• InChiKey: JNANCCREFMIVHM-BDBRCDPUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  ergosta-5,7,14,22t-tetraen-3β-ol 在 aluminum tri-tert-butoxide 、 丙酮 作用下， 生成 麦角甾-4,6,8(14),22-四烯-3-酮
  参考文献：
  名称：

  607.一种来自黑曲霉菌株的新固醇

  摘要：

  DOI：

  10.1039/jr9510002728

文献信息

• FERMENTATION PRODUCT OF A CEREAL-DERIVED MATERIAL AND IMMUNOMODULATOR
  申请人：Kirin Holdings Kabushiki Kaisha

  公开号：EP2446754A1

  公开（公告）日：2012-05-02

  The present invention provides dendritic cells (DCs) having reduced inflammatory activity, a method for producing DCs capable of inducing regulatory T cells and regulatory T cells, and substances useful for such a method, wherein the DCs and regulatory T cells are useful for prevention and treatment of immune diseases. The present invention relates to a cereal plant-derived material fermented with a koji microorganism, which is obtained by fermentation thereof with a koji microorganism, or a processed product thereof. Preferably, the fermented product or a processed product thereof comprises 14-dehydroergosterol. According to the present invention, regulatory DCs and regulatory T cells can be induced and the proliferation of inflammatory T cells can be suppressed using plant-derived materials.

  本发明提供了具有降低炎症活性的树突状细胞（DCs）、生产能够诱导调节性T细胞和调节性T细胞的DCs的方法以及用于这种方法的物质，其中DCs和调节性T细胞可用于预防和治疗免疫疾病。本发明涉及一种用麴微生物发酵得到的谷类植物衍生材料，或其加工产品。优选地，发酵产品或其加工产品包含 14-脱氢麦角甾醇。根据本发明，可以使用植物衍生材料诱导调节性 DC 和调节性 T 细胞，并抑制炎性 T 细胞的增殖。
• FERMENTATION PRODUCT OF CEREAL PLANT-DERIVED MATERIAL AND IMMUNOMODULATOR
  申请人：Fujiwara Daisuke

  公开号：US20120094328A1

  公开（公告）日：2012-04-19

  The present invention provides dendritic cells (DCs) having reduced inflammatory activity, a method for producing DCs capable of inducing regulatory T cells and regulatory T cells, and substances useful for such a method, wherein the DCs and regulatory T cells are useful for prevention and treatment of immune diseases. The present invention relates to a cereal plant-derived material fermented with a koji microorganism, which is obtained by fermentation thereof with a koji microorganism, or a processed product thereof. Preferably, the fermented product or a processed product thereof comprises 14-dehydroergosterol. According to the present invention, regulatory DCs and regulatory T cells can be induced and the proliferation of inflammatory T cells can be suppressed using plant-derived materials.
• US9101566B2
  申请人：——

  公开号：US9101566B2

  公开（公告）日：2015-08-11
• 607. A new sterol from a strain of Aspergillus niger
  作者：D. H. R. Barton、T. Bruun

  DOI：10.1039/jr9510002728

  日期：——