4-((6-Amino-2-(2-methoxyethoxy)-8-oxo-7,8-dihydro-9H-purin-9-yl)methyl)benzonitrile | 1096159-02-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 4-((6-Amino-2-(2-methoxyethoxy)-8-oxo-7,8-dihydro-9H-purin-9-yl)methyl)benzonitrile
• 英文别名: 4-[[6-amino-2-(2-methoxyethoxy)-8-oxo-7H-purin-9-yl]methyl]benzonitrile
• CAS: 1096159-02-2
• 化学式: C₁₆H₁₆N₆O₃
• 分子量: 340.34
• InChiKey: DNESSYDERLMQBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  126
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] PURINE DERIVATIVES AND THEIR USE AS MODULATORS OF TOLL-LIKE RECEPTOR 7<br/>[FR] DÉRIVÉS DE PURINE ET LEUR UTILISATION COMME MODULATEURS DU RÉCEPTEUR DE TYPE TOLL-7
  申请人：GILEAD SCIENCES INC

  公开号：WO2009005687A1

  公开（公告）日：2009-01-08

  The present application includes purine compounds of Formula I or II: or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods that include the administration of such compounds with at least one additional active agent. Said compounds are used as modulators of Toll -like receptor 7.

  本申请包括式I或II的嘌呤化合物：或其药用可接受的盐、溶剂和/或酯，含有这些化合物的组合物，包括给予这些化合物的治疗方法，以及包括给予这些化合物和至少一种额外活性剂的治疗方法。所述化合物被用作调节Toll样受体7的调节剂。
• Modulators of toll-like receptor 7
  申请人：Graupe Micheal

  公开号：US20090047249A1

  公开（公告）日：2009-02-19

  The present application includes a compound of Formula I or II: or a pharmaceutically acceptable-salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods that include the administration of such compounds with at least one additional active agent.

  本申请涵盖了公式I或II的化合物： 或其药学上可接受的盐、溶剂合物和/或酯，包含这些化合物的组合物，包括这些化合物的给药的治疗方法，以及包括这些化合物与至少一种额外活性剂的给药的治疗方法。
• MODULATORS OF TOLL-LIKE RECEPTOR 7
  申请人：Graupe Michael

  公开号：US20120244121A1

  公开（公告）日：2012-09-27

  The present invention includes therapeutic methods that include the administration of a compound of Formula I or II: or a pharmaceutically acceptable salt, solvate, and/or ester thereof, to a subject in need of such, and therapeutic methods that include the administration of such compounds with at least one additional active agent.

  本发明包括治疗方法，其中包括将I或II式化合物：或其药学上可接受的盐，溶剂化合物和/或酯剂，给予需要此类治疗的受试者，并且包括将这些化合物与至少一种其他活性剂一起给予的治疗方法。
• IMMUNE RECEPTOR MODIFIER CONJUGATE AND PREPARATION METHOD AND USE THEREOF, COUPLING PRECURSOR FOR PREPARING SAME, AND COMPOUND FOR SYNTHESIZING COUPLING PRECURSOR
  申请人：Shenzhen University

  公开号：EP2918596A1

  公开（公告）日：2015-09-16

  Disclosed is an immune receptor modifier conjugate, obtained from the reaction between a coupling precursor and a biotic ligand, the coupling precursor being a 9-position aminomethyl benzyl purine biotic coupling precursor, and the biotic ligand being selected from one or more of polypeptide, protein, glycoprotein, polysaccharide, polynucleotide, inactivated cells and inactivated microbes. The immune receptor modifier couplet can be used for immunomodulation, antibody preparation, anti-virus, diabetes, tumor immunomodulation, and tumor bio-immunotherapy. The conjugate compounds or salts thereof can be prepared into various therapeutic drugs, and can be prepared into a compound drug together with other drugs, or pharmaceutically acceptable carrier composites or conjugates. Also disclosed are compounds for synthesizing the coupling precursor and salts thereof.

  本发明公开了一种免疫受体修饰剂偶联物，由偶联前体和生物配体反应得到，偶联前体为9位氨基甲基苄基嘌呤生物偶联前体，生物配体选自多肽、蛋白质、糖蛋白、多糖、多核苷酸、灭活细胞和灭活微生物中的一种或多种。免疫受体修饰剂偶联物可用于免疫调节、抗体制备、抗病毒、糖尿病、肿瘤免疫调节和肿瘤生物免疫疗法。共轭化合物或其盐可以制备成各种治疗药物，可以与其他药物一起制备成复合药物，也可以制备成药学上可接受的载体复合物或共轭物。还公开了用于合成偶联前体及其盐的化合物。
• Immune receptor modifier conjugate and preparation method and use thereof, coupling precursor for preparing same, and compound for synthesizing coupling precursor
  申请人：Shenzhen University

  公开号：US10030066B2

  公开（公告）日：2018-07-24

  Disclosed is an immune receptor modifier conjugate, obtained from the reaction between a coupling precursor and a biotic ligand, the coupling precursor being a 9-position aminomethyl benzyl purine biotic coupling precursor, and the biotic ligand being selected from one or more of polypeptide, protein, glycoprotein, polysaccharide, polynucleotide, inactivated cells and inactivated microbes. The immune receptor modifier couplet can be used for immunomodulation, antibody preparation, anti-virus, diabetes, tumor immunomodulation, and tumor bio-immunotherapy. The conjugate compounds or salts thereof can be prepared into various therapeutic drugs, and can be prepared into a compound drug together with other drugs, or pharmaceutically acceptable carrier composites or conjugates. Also disclosed are compounds for synthesizing the coupling precursor and salts thereof.

  本发明公开了一种免疫受体修饰剂偶联物，由偶联前体和生物配体反应得到，偶联前体为9位氨基甲基苄基嘌呤生物偶联前体，生物配体选自多肽、蛋白质、糖蛋白、多糖、多核苷酸、灭活细胞和灭活微生物中的一种或多种。免疫受体修饰剂偶联物可用于免疫调节、抗体制备、抗病毒、糖尿病、肿瘤免疫调节和肿瘤生物免疫疗法。共轭化合物或其盐可以制备成各种治疗药物，可以与其他药物一起制备成复合药物，也可以制备成药学上可接受的载体复合物或共轭物。还公开了用于合成偶联前体及其盐的化合物。