2,5-di-tert-butylaminemethyl-3,6-dimethyl pyrazine | 1354824-55-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2,5-di-tert-butylaminemethyl-3,6-dimethyl pyrazine
• 英文别名: 2,5-di-(tert-butylaminomethyl)-3,6-dimethylpyrazine；N-[[5-[(tert-butylamino)methyl]-3,6-dimethylpyrazin-2-yl]methyl]-2-methylpropan-2-amine
• CAS: 1354824-55-7
• 化学式: C₁₆H₃₀N₄
• 分子量: 278.441
• InChiKey: LJMNUZXYCNVSEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  49.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,5-di-tert-butylaminemethyl-3,6-dimethyl pyrazine 在 sodium tungstate (VI) dihydrate 、 双氧水 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以32%的产率得到2,5-[[(1,1-dimethylethyl)oxidoimino]methyl]-3,6-dimethylpyrazine
  参考文献：
  名称：

  [EN] PYRAZINE DERIVATIVES,PROCESS FOR MANUFACTURE AND USE THEREOF
  [FR] DÉRIVÉS DE PYRAZINE, LEUR PROCÉDÉ DE PRÉPARATION ET LEUR UTILISATION

  摘要：

  本文披露了式（I）的吡嗪衍生物及其药用可接受盐，其中提供了R1、R2、R3和R4的指定。披露了制备这些化合物的合成方法。披露了这些化合物的使用方法和含有它们的药物组合物，用于治疗和/或预防疾病以及制造药物。这些化合物和药物组合物具有抗氧化和溶栓作用，因此可用于治疗和/或预防由缺血引起的脑卒中，并用于制造用于治疗和/或预防由自由基和/或血栓形成引起的神经系统疾病、传染病、代谢系统疾病、心血管和脑血管疾病以及与年龄相关的退行性疾病的药物。

  公开号：

  WO2012003784A1

文献信息

• PYRAZINE DERIVATIVES,PROCESS FOR MANUFACTURE AND USE THEREOF
  申请人：Ji Nan University

  公开号：EP2513072A1

  公开（公告）日：2012-10-24
• PYRAZINE DERIVATIVES, PROCESS FOR MANUFACTURE AND USE THEREOF
  申请人：Wang Yuqiang

  公开号：US20120115874A1

  公开（公告）日：2012-05-10

  The present invention provides pyrazine derivatives of formula I and pharmaceutically acceptable salts thereof, wherein the designation of R 1 , R 2 , R 3 and R 4 is provided herein. The invention also provides syntheses for preparation of such compounds. The invention further provides methods of use of these compounds and pharmaceutical compositions containing them for treatment and/or prevention of diseases and for manufacture of medicaments. These compounds and pharmaceutical compositions have antioxidative and thrombolytic effects, and thus can be used for the treatment and/or prevention of cerebral stroke caused by ischemia, and used for manufacture of medicaments for the treatment and/or prevention of nervous system diseases caused by excessive amount of radicals and/or thrombosis, infectious diseases, metabolic system diseases, cardiovascular and cerebrovascular diseases, and age-related degenerative diseases.
• US8796281B2
  申请人：——

  公开号：US8796281B2

  公开（公告）日：2014-08-05
• [EN] PYRAZINE DERIVATIVES,PROCESS FOR MANUFACTURE AND USE THEREOF<br/>[FR] DÉRIVÉS DE PYRAZINE, LEUR PROCÉDÉ DE PRÉPARATION ET LEUR UTILISATION
  申请人：UNIV JINAN

  公开号：WO2012003784A1

  公开（公告）日：2012-01-12

  Pyrazine derivatives of formula (I) and pharmaceutically acceptable salts thereof are disclosed, wherein the designation of R1, R2, R3 and R4 are provided herein. Syntheses for preparation of such compounds are disclosed. Methods of use of these compounds and pharmaceutical compositions containing them for treatment and/or prevention of diseases and for manufacture of medicaments are disclosed. These compounds and pharmaceutical compositions have antioxidative and thrombolytic effects, and thus can be used for the treatment and/or prevention of cerebral stroke caused by ischemia, and used for manufacture of medicaments for the treatment and/or prevention of nervous system diseases caused by excessive amount of radicals and/or thrombosis, infectious diseases, metabolic system diseases, cardiovascular and cerebrovascular diseases, and age-related degenerative diseases.

  本文披露了式（I）的吡嗪衍生物及其药用可接受盐，其中提供了R1、R2、R3和R4的指定。披露了制备这些化合物的合成方法。披露了这些化合物的使用方法和含有它们的药物组合物，用于治疗和/或预防疾病以及制造药物。这些化合物和药物组合物具有抗氧化和溶栓作用，因此可用于治疗和/或预防由缺血引起的脑卒中，并用于制造用于治疗和/或预防由自由基和/或血栓形成引起的神经系统疾病、传染病、代谢系统疾病、心血管和脑血管疾病以及与年龄相关的退行性疾病的药物。