4-[2-[3,5-dichloro-2-[(2,2-dimethyl-3H-1-benzofuran-7-yl)oxymethyl]-6-oxopyridin-1-yl]ethyl]benzoic acid | 1091596-42-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 香豆素
• 英文名称: 4-[2-[3,5-dichloro-2-[(2,2-dimethyl-3H-1-benzofuran-7-yl)oxymethyl]-6-oxopyridin-1-yl]ethyl]benzoic acid
• CAS: 1091596-42-7
• 化学式: C₂₅H₂₃Cl₂NO₅
• 分子量: 488.367
• InChiKey: VCXMYBYNJWDLLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  76.1
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• PYRIDONE COMPOUND
  申请人：Kamikubo Takashi

  公开号：US20100179137A1

  公开（公告）日：2010-07-15

  [Solving Means] The present inventors have conducted extensive studies on an EP4 receptor agonist, and as a result, found that a novel pyridone compound characterized in that the 1-position in the pyridone ring is substituted with a group having an acidic group such as a carboxyl group and the 6-position is bonded with an aromatic ring group via lower alkyl, lower alkylene, ether, or thioether, has an excellent EP4 receptor agonistic action, thereby completing the present invention. Since the compound of the present invention has an excellent EP4 receptor agonistic action and a blood flow increasing action in the hindlimb of a rat, it is useful as a pharmaceutical, in particular, an agent for treating peripheral arterial occlusive disease.

  【解决方法】本发明者对EP4受体激动剂进行了广泛的研究，并发现一种新型吡啶酮化合物，其特征在于吡啶酮环中的1位被取代为具有酸性基团（如羧基）的基团，而6位则通过较低的烷基、烷基烷基、醚或硫醚与芳香环基团结合，具有极好的EP4受体激动作用，从而完成了本发明。由于本发明的化合物在大鼠后肢具有出色的EP4受体激动作用和增加血流的作用，因此可用作制药用途，特别是治疗周围动脉闭塞性疾病的药物。