(2-(Dimethylamino)pyridin-3-yl)methanol | 104524-65-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (2-(Dimethylamino)pyridin-3-yl)methanol
• 英文别名: [2-(dimethylamino)pyridin-3-yl]methanol
• CAS: 104524-65-4
• 化学式: C₈H₁₂N₂O
• mdl: MFCD14605896
• 分子量: 152.19
• InChiKey: HMHBUFYQGHBUHZ-UHFFFAOYSA-N

物化性质

• 沸点：
  287.6±30.0 °C(Predicted)
• 密度：
  1.131±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.375
• 拓扑面积：
  36.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2-(Dimethylamino)pyridin-3-yl)methanol 生成 3-(chloromethyl)-N,N-dimethylpyridin-2-amine
  参考文献：
  名称：

  摘要：

  DOI：
• 作为产物：
  描述：

  Methyl 2-(dimethylamino)nicotinate 生成 (2-(Dimethylamino)pyridin-3-yl)methanol
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• [EN] METHOD OF USING (H/K) ATPase INHIBITORS AS ANTIVIRAL AGENTS<br/>[FR] PROCEDE D'UTILISATION D'INHIBITEURS DE (H/K)ATPASE COMME AGENTS ANTIVIRAUX
  申请人：G.D. SEARLE & CO.

  公开号：WO1995029897A1

  公开（公告）日：1995-11-09

  (EN) A class of compounds which are (H+/K+) ATPase inhibitors can be used for the treatment of viral infections. Compounds of particular interest are defined by formula (III), wherein D is N or CH; wherein R7 is one or more radicals selected from hydrido, alkoxy, amino, cyano, nitro, hydroxyl, alkyl, halo, haloalkyl, carboxyl, alkanoyl, nitro, amino, alkylamino, aminocarbonyl, aminosulfonyl, alkylaminocarbonyl, alkylcarbonylamino, alkoxycarbonyl, alkylaminosulfonyl, alkylsulfonylamino, alkylthio, alkylsulfinyl and alkylsulfonyl; wherein R8 is selected from hydrido, alkyl and cycloalkyl; wherein R9 is one or more radicals selected from hydrido, alkoxy, amino, alkyl, halo, cyano, nitro, hydroxyl, haloalkyl, nitro, carboxyl, alkanoyl, amino, alkylamino, dialkylamino, aminocarbonyl, alkylaminocarbonyl, alkylcarbonylamino, aminosulfonyl, alkylaminosulfonyl, alkylsulfonylamino, alkoxycarbonyl, alkylthio, alkylsulfinyl and alkylsulfonyl; and wherein R10 and R11 are independently selected from hydrido, alkyl, aryl, alkylcarbonyl and arylcarbonyl wherein the aryl ring may be further substituted with one or more radicals selected from alkyl, halo, hydrazidylcarbonyl, aminocarbonyl and alkoxy; or wherein R10 and R11 together with the nitrogen atom form a heterocyclic ring; or a pharmaceutically acceptable salt thereof.(FR) Une classe de composés qui sont des inhibiteurs de (H+/K+)ATPase peut être utilisée pour le traitement d'infections virales. Les composés particuliers à examiner sont définis par la formule (III), dans laquelle D représente N ou CH; R7 représente un ou plusieurs radicaux choisis entre hydrido, alcoxy, amino, cyano, nitro, hydroxyle, alkyle, halo, haloalkyle, carboxyle, alcanoyle, nitro, amino, alkylamino, aminocarbonyle, aminosulfonyle, alkylaminocarbonyle, alkylcarbonylamino, alcoxycarbonyle, alkylaminosulfonyle, alkylsulfonylamino, alkylthio, alkylsulfinyle et alkylsulfonyle; R8 est choisi entre hydrido, alkyle et cycloalkyle; R9 représente un ou plusieurs radicaux choisis entre hydrido, alcoxy, amino, alkyle, halo, cyano, nitro, hydroxyle, haloalkyle, nitro, carboxyle, alcanoyle, amino, alkylamino, dialkylamino, aminocarbonyle, alkylaminocarbonyle, alkylcarbonylamino, aminosulfonyle, alkylaminosulfonyle, alkylsulfonylamino, alcoxycarbonyle, alkylthio, alkylsulfinyle, et alkylsulfonyle; et R10 et R11 sont indépendamment choisis entre hydrido, alkyle, aryle, alkylcarbonyle, et arylcarbonyle, le noyau aryle pouvant être en outre substitué par un ou plusieurs radicaux choisis entre alkyle, halo, hydrazidylcarbonyle, aminocarbonyle et alcoxy; ou R10 et R11 forment avec l'atome d'azote un noyau hétérocyclique; ou leur sel pharmaceutiquement acceptable.

  一类(H+/K+) ATPase抑制剂化合物可用于治疗病毒感染。特别感兴趣的化合物由公式(III)定义，其中D是N或CH；R7是一个或多个从氢基，烷氧基，氨基，氰基，硝基，羟基，烷基，卤基，卤基烷基，羧基，烷酰基，硝基，氨基，烷基氨基，氨基甲酰基，氨基磺酰基，烷基氨基甲酰基，烷基羰基氨基，烷氧羰基，烷基氨基磺酰基，烷基磺酰胺基，烷硫基，烷基亚磺酰基和烷基磺酰基中选择的基团；R8选择从氢基，烷基和环烷基中选择；R9是一个或多个从氢基，烷氧基，氨基，烷基，卤基，氰基，硝基，羟基，卤基烷基，硝基，羧基，烷酰基，氨基，烷基氨基，二烷基氨基，氨基甲酰基，烷基氨基甲酰基，烷氧羰基，烷基氨基磺酰基，烷基磺酰胺基，烷基亚磺酰基，烷氧羰基，烷硫基，烷基亚磺酰基和烷基磺酰基中选择的基团；R10和R11分别选择从氢基，烷基，芳基，烷基羰基和芳基羰基中选择，其中芳环可以进一步取代一个或多个从烷基，卤基，肼基羰基，氨基羰基和烷氧基中选择的基团；或者R10和R11与氮原子一起形成杂环环；或其药学上可接受的盐。
• Method of using (H+/K+) ATPase inhibitors as antiviral agents
  申请人：——

  公开号：US20010047038A1

  公开（公告）日：2001-11-29

  A class of compounds which are (H + /K + )ATPase inhibitors can be used for the treatment of viral infections. Compounds of particular interest are defined by Formula III: 1 wherein D is N or CH; wherein R 7 is one or more radicals selected from hydrido, alkoxy, amino, cyano, nitro, hydroxyl, alkyl, halo, haloalkyl, carboxyl, alkanoyl, nitro, amino, alkylamino, amide, alkylamide, alkoxycarbonyl, alkylthio, alkylsulfinyl and alkylsulfonyl; wherein R 9 is one or more radicals selected from hydrido, alkoxy, amino, alkyl, halo, cyano, nitro, hydroxyl, haloalkyl, carboxyl, alkanoyl, nitro, amine, alkylamine, dialkylamine, amide, alkylamide, alkoxycarbonyl, alkylthio, alkylsulfinyl and alkylsulfonyl; and wherein R 10 and R 11 are independently selected from hydrido and alkyl; or a pharmaceutically acceptable salt thereof.

  一类(H+/K+)ATP酶抑制剂类化合物可用于治疗病毒感染。特别感兴趣的化合物由公式III:1定义，其中D为N或CH; R7为一个或多个基团，选自氢，烷氧基，氨基，氰基，硝基，羟基，烷基，卤素基，卤代烷基，羧基，烷酰基，硝基，氨基，烷基氨基，酰胺，烷基酰胺，烷氧羰基，烷基硫醇基，烷基亚砜基和烷基磺酰基; R9为一个或多个基团，选自氢，烷氧基，氨基，烷基，卤素基，氰基，硝基，羟基，卤代烷基，羧基，烷酰基，硝基，胺基，烷基胺基，二烷基胺基，酰胺，烷基酰胺，烷氧羰基，烷基硫醇基，烷基亚砜基和烷基磺酰基; R10和R11独立选择自氢和烷基; 或其药学上可接受的盐。
• Method of using (H.sup.+ /K.sup.+)ATPase inhibitors as antiviral agents
  申请人：G.D. Searle & Co.

  公开号：US05945425A1

  公开（公告）日：1999-08-31

  A class of compounds which are (H.sup.+ /K.sup.+)ATPase inhibitors can be used for the treatment of viral infections. Compounds of particular interest are defined by Formula III: ##STR1## wherein D is N or CH; wherein R.sup.7 is one or more radicals selected from hydrido, alkoxy, amino, cyano, nitro, hydroxyl, alkyl, halo, haloalkyl, carboxyl, alkanoyl, nitro, amino, alkylamino, aminocarbonyl, aminosulfonyl, alkylaminocarbonyl, alkylcarbonylamino, alkoxycarbonyl, alkylaminosulfonyl, alkylsulfonylamino, alkylthio, alkylsulfinyl and alkylsulfonyl; wherein R.sup.8 is selected from hydrido, alkyl and cycloalkyl; wherein R.sup.9 is one or more radicals selected from hydrido, alkoxy, amino, alkyl, halo, cyano, nitro, hydroxyl, haloalkyl, nitro, carboxyl, alkanoyl, amino, alkylamino, dialkylamino, aminocarbonyl, alkylaminocarbonyl, alkylcarbonylamino, aminosulfonyl, alkylaminosulfonyl, alkylsulfonylamino, alkoxycarbonyl, alkylthio, alkylsulfinyl and alkylsulfonyl; and wherein R.sup.10 and R.sup.11 are independently selected from hydrido, alkyl, aryl, alkylcarbonyl and arylcarbonyl wherein the aryl ring may be further substituted with one or more radicals selected from alkyl, halo, hydrazidylcarbonyl, aminocarbonyl and alkoxy; or wherein R.sup.10 and R.sup.11 together with the nitrogen atom form a heterocyclic ring.

  一类(H.sup.+ /K.sup.+)ATPase抑制剂化合物可用于治疗病毒感染。特别感兴趣的化合物由公式III定义：##STR1## 其中D为N或CH；其中R.sup.7是一个或多个从氢，烷氧基，氨基，氰基，硝基，羟基，烷基，卤基，卤代烷基，羧基，烷酰基，硝基，烷基氨基，氨基甲酰基，氨基磺酰基，烷基氨基甲酰基，烷基羧酰胺，烷氧羰基，烷基氨基磺酰基，烷基磺酰氨基，烷硫基，烷基亚磺酰基和烷基磺酰基中选择的一个或多个基团；其中R.sup.8选择自氢，烷基和环烷基；其中R.sup.9是一个或多个从氢，烷氧基，氨基，烷基，卤基，氰基，硝基，羟基，卤代烷基，硝基，羧基，烷酰基，氨基，烷基氨基，二烷基氨基，氨基甲酰基，烷基氨基甲酰基，氨基磺酰基，烷基氨基磺酰基，烷基磺酰氨基，烷氧羰基，烷硫基，烷基亚磺酰基和烷基磺酰基中选择的一个或多个基团；其中R.sup.10和R.sup.11分别选择自氢，烷基，芳基，烷基羰基和芳基羰基，其中芳环可能进一步用一个或多个从烷基，卤基，肼基羰基，氨基羰基和烷氧基中选择的基团取代；或者其中R.sup.10和R.sup.11与氮原子一起形成杂环环。
• Benzimidazoles, and their production formulation and use as gastric acid secretion inhibitors
  申请人：FISONS plc

  公开号：EP0174717A1

  公开（公告）日：1986-03-19

  There are described compounds of formula I, in which Rc is a nucleophilic nitrogen, oxygen or sulphur separated from the SO group by 1, 2, 3, 4 or 5 other atoms, R1, R1,R3 and R4, which may be the same or different, are each hydrogen, halogen, alkoxy, alkyl, fluoroalkyl, alkanoyl, RS(O)n-, -NO2, -N(R)2, -NHCOR, or -COOH or an ester or amide thereof, or an adjacent pair of R1, R2, R3 and R4 may in addition to the values given above, together form a chain -(CH2)x- or, together with the carbon atoms to which they are attached, form a 6 membered unsaturated carboxylic or nitrogen heterocyclic ring, x is 3, 4 or 5, n is 0, 1 or 2, X is 0, S or NR15, R15 is hydrogen, -COR, -COOR or alkyl which latter is optionally substituted by -OCOR, R is phenyl, or alkyl optionally substituted by phenyl, the phenyl groups in turn optionally being substituted by alkyl, provided that i) Rc is not -CH2CH2-morpholino, ii) that when Rc is a nitrogen nucleophile carried on an aryl or heteroaryl group R,5 is not a group -COR in which R is unsubstituted alkyl, iii) when X is NR15 Rc does not comprise an unsaturated nitrogen heterocyclic ring other than such a ring substituted by a either a) a substituted or unsubstituted amino group, or b) an N-oxido group, and iv) when X is NR15 Rc does not comprise an alkyl group substituted by an optionally alkyl or halo substitute piperidino group, and pharmaceutically acceptable salts thereof. There are also described processes for making the compounds, and their formulation and use as pharmaceuticals, e.g. to treat gastric acid secretion.

  所述化合物为式 I、 其中 Rc 是亲核的氮、氧或硫，与 SO 基团之间隔着 1、2、3、4 或 5 个原子、 R1、R1、R3 和 R4（可以相同或不同）各自为氢、卤素、烷氧基、烷基、氟烷基、烷酰基、RS(O)n-、-NO2、-N(R)2、-NHCOR 或 -COOH 或其酯或酰胺、 或相邻的一对 R1、R2、R3 和 R4 除上述数值外，还可共同形成链-(CH2)x-，或与它们所连接的碳原子一起形成一个 6 个成员的不饱和羧基或氮杂环、 x 是 3、4 或 5、 n 是 0、1 或 2、 X 是 0、S 或 NR15、 R15 是氢、-COR、-COR 或烷基，后者任选被-OCOR 取代、 R 是苯基，或任选被苯基取代的烷基，苯基又任选被烷基取代、 条件是 i) Rc 不是- -吗啉基，ii) 当 Rc 是芳基或杂芳基上携带的亲氮核物时，R,5 不是基团-COR，其中 R 是未取代的烷基、iii) 当 X 为 NR15 时，Rc 不包括不饱和氮杂环，但被 a）取代或未取代的氨基或 b）N-氧代基团取代的环除外；以及 iv) 当 X 为 NR15 时，Rc 不包括被任选烷基或卤代哌啶基取代的烷基、 及其药学上可接受的盐类。 此外，还描述了制造这些化合物的工艺，以及它们作为药物的配制和使用，例如用于治疗胃酸分泌。
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