3-(1,3-Dioxo-3a,4,7,7a-tetrahydro-4,7-epoxyisoindol-2-yl)propanoic acid | 943333-16-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 3-(1,3-Dioxo-3a,4,7,7a-tetrahydro-4,7-epoxyisoindol-2-yl)propanoic acid
• CAS: 943333-16-2
• 化学式: C₁₁H₁₁NO₅
• 分子量: 237.212
• InChiKey: TWFYJWGDQDMIGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  83.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-(1,3-Dioxo-3a,4,7,7a-tetrahydro-4,7-epoxyisoindol-2-yl)propanoic acid 、 在 1,3-二苯基四甲基二硅氮烷 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以82%的产率得到
  参考文献：
  名称：

  PHENYLTETRAENE-BASED NONLINEAR OPTICAL CHROMOPHORES

  摘要：

  含有烷氧基取代苯基四烯非线性光学活性化合物、包括这些化合物的薄膜和器件，以及制备和使用这些化合物、薄膜和器件的方法。

  公开号：

  US20100029953A1

文献信息

• Block copolymer and micelle compositions and methods of use thereof
  申请人：The Board of Regents of the University of Texas System

  公开号：US10017598B2

  公开（公告）日：2018-07-10

  Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

  本文提供的嵌段共聚物包括亲水性聚合物段和疏水性聚合物段，其中亲水性聚合物段包括选自以下组别的聚合物：聚环氧乙烷（PEO）、聚甲基丙烯酸酯磷脂酰胆碱（MPC）和聚乙烯吡咯烷酮（PVP），其中疏水性聚合物段包括 其中 R′为-H 或-CH3，其中 R 为-NR1R2，其中 R1 和 R2 为烷基，其中 R1 和 R2 相同或不同，其中 R1 和 R2 共具有 5 至 16 个碳原子，其中 R1 和 R2 可任选连接形成环，其中 n 为 1 至约 10，以及 x 共约 20 至约 200。还提供了用于治疗和诊断的 pH 敏感胶束组合物。
• POLYMERS, POLYMER MEMBRANES AND METHODS OF PRODUCING THE SAME
  申请人：Air Products and Chemicals, Inc.

  公开号：EP2569081A1

  公开（公告）日：2013-03-20
• NOVEL BLOCK COPOLYMER AND MICELLE COMPOSITIONS AND METHODS OF USE THEREOF
  申请人：The Board of Regents of the University of Texas System

  公开号：EP2619238B1

  公开（公告）日：2017-03-08
• CROSSLINKED CELLULOSIC POLYMERS
  申请人：Carlson William B.

  公开号：US20130142763A1

  公开（公告）日：2013-06-06

  Crosslinked cellulosic polymers, crosslinked cellulosic polymer hydro-gels, and methods for their synthesis and use are described. The crosslinked cellulosic polymers include one or more cellulosic polymers and a one or more crosslinkers that crosslinks the one or more cellulosic polymers together. The crosslinking can be facilitated with a crosslinking agent capable of linking with a monomer the cellulosic polymer and crosslinking the cellulosic polymer intermoleculerly and/or intramolecularly. Crosslinked cellulosic polymers are well adapted for use in cell and tissue growth in vivo and in vitro. The crosslinked cellulose polymers may also be used as wound care devices.
• MULTICOLORED pH-ACTIVATABLE FLUORESCENCE NANOPLATFORM
  申请人：The Board of Regents of the University of Texas System

  公开号：US20170049911A1

  公开（公告）日：2017-02-23

  The present invention relates to pH-tunable, highly activatable multicolored fluorescent nanoplatforms and methods of using the nanoplatforms in a variety of applications including, but not limited to, investigating fundamental cell physiological processes such as pH regulation in endocytic vesicles, endosome/lysosome maturation, and effect of pH on receptor cycling and trafficking of subcellular organelles.