N-3-nitrosalicylaldehyde aniline | 15677-17-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N-3-nitrosalicylaldehyde aniline
• 英文别名: 2-Hydroxy-3-nitro-benzaldehyd-phenylimin；2-Nitro-6-(phenylimino-methyl)-phenol；N-<3-Nitro-salicyliden>-anilin；3-Nitro-2-hydroxybenzylidenanilin；3-Nitro-salicylaldehyd-anil；3-Nitro-salicyliden-anilin；2-Nitro-6-[(phenylimino)methyl]phenol；2-nitro-6-(phenyliminomethyl)phenol
• CAS: 15677-17-5
• 化学式: C₁₃H₁₀N₂O₃
• mdl: MFCD00989809
• 分子量: 242.234
• InChiKey: INLFWHLZZKENEJ-UHFFFAOYSA-N

物化性质

• 沸点：
  374.0±32.0 °C(Predicted)
• 密度：
  1.25±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-3-nitrosalicylaldehyde aniline 以 乙醇 、 二甲基亚砜 为溶剂， 反应 8.0h， 生成
  参考文献：
  名称：

  Multi-properties of a Cu(II) complex: Crystal structure, anion binding ability, bioactivity and cell cytotoxicity

  摘要：

  A new copper(II) complex based on Schiff bases of 3-nitrosalicylaldehyde was synthesized and the crystal was also obtained fortunately. Its structure was well characterized by single-crystal X-ray diffraction and HRMS. The complex showed the strongest binding ability and high selectivity for hydrogen sulfide among other anions (AcO-, H2PO4-, F-, Cl-, Br- and I-) at neutral pH in organic-aqueous solutions. The possible mechanism was the copper ion was released and combined with hydrogen sulfide after the anion was added. In addition, the further application of the sensor was applied to hela cells cytotoxicity. The above results indicated the copper(II) complex could be used as a sensor for the detection of HS- in the sample of environment, pharmacy, and etc. More importantly, the copper(II) complex also exhibited effective and wide antibacterial activity. (C) 2016 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2016.10.046
• 作为产物：
  描述：

  3-硝基水杨醛 、 苯胺 以 甲苯 为溶剂， 反应 6.0h， 生成 N-3-nitrosalicylaldehyde aniline
  参考文献：
  名称：

  通过有机催化多组分二烯胺介导的一锅级联的桥联苯并恶唑啉的不对称形成。

  摘要：

  提出了一种有机催化的一锅级联反应，可导致新型桥联苯并恶唑啉酮的立体选择性形成。所开发的方法基于γ-选择性曼尼希引发的级联反应的第一个实例，并允许通过掺入各种α，β-不饱和醛，富电子苯胺和电子不足的水杨醛直接桥接的苯并恶唑啉。产品的综合适用性通过相关的转换得到了证明。

  DOI：

  10.1021/ol501882x

文献信息

• Ichibagase, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1955, vol. 75, p. 1483,1485
  作者：Ichibagase

  DOI：——

  日期：——
• ——
  作者：V. L. Abramenko

  DOI：10.1023/a:1012575224360

  日期：——

  Molecular complexes of MoOCl4 with benzal- and salicylalanilines were synthesized, and their IR spectra were investigated. The complexes have octahedral structure. Salicylalaniline and its derivatives were suggested to be coordinated by the central atom through the carbonyl oxygen atom of quinoid tautomeric form.