[Cu(resacetophenone oxime-1H)2(imidazole)2] | 929704-27-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: [Cu(resacetophenone oxime-1H)2(imidazole)2]
• CAS: 929704-27-8
• 化学式: C₂₂H₂₄CuN₆O₆
• 分子量: 532.015
• InChiKey: LFUPBPNVVQUCKG-AWMDRZOWSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  咪唑 、 [Cu(resacetophenone oxime-1H)2] 以 二氯甲烷 为溶剂， 生成 [Cu(resacetophenone oxime-1H)2(imidazole)2]
  参考文献：
  名称：

  Synthesis, characterization, DNA interaction and cleavage activity of new mixed ligand copper(II) complexes with heterocyclic bases

  摘要：

  Mixed ligand complexes having the formulae Cu(RPO)(2)PY2, Cu(RPO)(2)Im(2), and Cu(DBO)(2)Py-2 [RPO = resacetophenone oxime, DBO = 2,4-dihydroxybenzophenone oxime, Py = pyridine and Ina = imidazole] have been synthesized and characterized by UV-Vis, IR, ESR, cyclic voltammetry and magnetic susceptibility methods. Absorption studies revealed that each of these octahedral complexes is an avid binder of calf thymus DNA. The apparent binding constants for mixed ligand complexes are in order of 10(4)-10(5) M-1. Based on the data obtained in the DNA binding studies a partial intercalative mode of binding is suggested for these complexes. The nucleolytic cleavage activity of the adducts was carried out on double stranded pBR322 circular plasmid DNA by using a gel electrophoresis experiment in the presence and absence of oxidant (H2O2). All the metal complexes cleaved supercoiled DNA by hydrolytic and oxidative paths. The oxidative path dominates the hydrolytic cleavage. The hydrolytic cleavage of DNA is evidenced from the control experiments showing discernable cleavage inhibition in the presence of the hydroxyl radical inhibitor DMSO or the singlet oxygen quencher azide ion. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2006.08.026