N-[1-cyano-1-(2-naphthyl)ethyl]-2-methyl-2-propanesulfonamide | 1020855-90-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-[1-cyano-1-(2-naphthyl)ethyl]-2-methyl-2-propanesulfonamide
• CAS: 1020855-90-6
• 化学式: C₁₇H₂₀N₂O₂S
• 分子量: 316.424
• InChiKey: BFQAFSISXOMKLP-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  (E)-2-methyl-N-(1-(naphthalen-2-yl)ethylidene)propane-2-sulfonamide 、 三甲基氰硅烷 在 NanoActive Plus magnesium oxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 以96%的产率得到N-[1-cyano-1-(2-naphthyl)ethyl]-2-methyl-2-propanesulfonamide
  参考文献：
  名称：

  Synthesis of α-amino nitriles through Strecker reaction of aldimines and ketoimines by using nanocrystalline magnesium oxide

  摘要：

  Strecker reactions of various aldimines as well as ketoimines with TMSCN proceeded smoothly under mild conditions to give the corresponding alpha-amino nitriles and alpha,alpha-disubstituted alpha-amino nitriles, respectively, in good to excellent yields in the presence of nanocrystalline magnesium oxide. The reaction proceeds through hypervalent silicate species by coordination to O2-/O- (Lewis basic site) of nanocrystalline magnesium oxide, proved by Si-29 NMR. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.01.128