2-tert-butyl-6-chloro-1(3)H-imidazo[4,5-b]pyridine | 21714-51-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 2-tert-butyl-6-chloro-1(3)H-imidazo[4,5-b]pyridine
• 英文别名: 2-tert-butyl-6-chloro-1H-imidazo[4,5-b]pyridine
• CAS: 21714-51-2
• 化学式: C₁₀H₁₂ClN₃
• 分子量: 209.678
• InChiKey: ILSGJYSBBGVTAO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Inhibitors of the unconventional secretion of fibroblast growth factor 2 (FGF2) by tumor cells and uses thereof
  申请人：Universität Heidelberg

  公开号：US10842793B2

  公开（公告）日：2020-11-24

  The present invention relates to compounds that have the capability of inhibiting the secretion of fibroblast growth factor 2 (FGF2) by tumor cells, as well as uses of said compound in medicine, in particular in the prevention and/or treatment of cancerous or inflammatory diseases.

  本发明涉及能够抑制肿瘤细胞分泌成纤维细胞生长因子 2（FGF2）的化合物，以及所述化合物在医学中的用途，特别是在预防和/或治疗癌症或炎症性疾病中的用途。
• Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US11203592B2

  公开（公告）日：2021-12-21

  The present invention provides compounds of formula (I): wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.

  本发明提供了式(I)化合物：其中所有变量如本文所定义。这些化合物是吲哚胺-2,3-二氧化酶（IDO）的抑制剂，可用作治疗癌症、病毒感染和/或自身免疫性疾病等增殖性疾病的药物。
• Inhibitors of the Unconventional Secretion of Fibroblast Growth Factor 2 (FGF2) by Tumor Cells and Uses Thereof
  申请人：Universität Heidelberg

  公开号：US20190307752A1

  公开（公告）日：2019-10-10

  The present invention relates to compounds that have the capability of inhibiting the secretion of fibroblast growth factor 2 (FGF2) by tumor cells, as well as uses of said compound in medicine, in particular in the prevention and/or treatment of cancerous or inflammatory diseases.
• INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20210221806A1

  公开（公告）日：2021-07-22

  The present invention provides compounds of formula (I): wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.