3-[1-(2,2-dimethyl-1,2,3,4-tetrahydrobenzo[f]isoquinolin-4-ylidene)-2-morpholino-2-oxoethyl]quinoxalin-2(1H)-one | 1133326-49-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-[1-(2,2-dimethyl-1,2,3,4-tetrahydrobenzo[f]isoquinolin-4-ylidene)-2-morpholino-2-oxoethyl]quinoxalin-2(1H)-one
• CAS: 1133326-49-4
• 化学式: C₂₉H₂₈N₄O₃
• 分子量: 480.566
• InChiKey: DFUUYQUOORTOQD-OCOZRVBESA-N

反应信息

• 作为产物：
  描述：

  11,11-dimethyl-3-(morpholine-4-carbonyl)-10H-naphtho[1,2-g]indolizine-1,2-dione 、 邻苯二胺 在 对甲苯磺酸 作用下， 以 异丙醇 为溶剂， 以76%的产率得到3-[1-(2,2-dimethyl-1,2,3,4-tetrahydrobenzo[f]isoquinolin-4-ylidene)-2-morpholino-2-oxoethyl]quinoxalin-2(1H)-one
  参考文献：
  名称：

  Synthesis of isoquinoline derivatives of quinoxalin-2-one from pyrrolo[2,1-a]isoquinoline-2,3-diones and o-phenylenediamine

  摘要：

  Reactions of 5,5-dialkyl-2,3,4,5-tetrahydropyrrolo[2,1-a]isoquinoline-2,3-diones with o-phenylenediamine in the presence of a catalytic amount of hydrogen chloride or p-toluenesulfonic acid involved opening of the pyrrole ring with formation of 3-(3,3-dialkyl-1,2,3,4-tetrahydroisoquinolin-1-ylidenemethyl)quinoxalin-2(1H)-ones. The presence of an enamine fragment in the products was confirmed by reaction with oxalyl chloride.

  DOI：

  10.1134/s1070428008060201